Gene: [11q11/OSBP] oxysterol binding protein;

FUN

The product of the OSBP gene is an intracellular protein participating in steroid transport from lysosomes to the nucleus where steroid compounds suppress the expression of genes of LDL receptor (GEM:19p132/LDLR) and some enzymes (GEM:05q1/HMGCR; GEM:05p1/HMGCS1; GEM:01p1/HMGCS2)."

REF

CLO,COD,EXP,LOC,EAG "Hsieh &: AJHG, 45, A143, 1989
CLO,COD,SEQ,EXP,LOC,EAG "Levanon D &: Genomics, 7, N1, 65-74, 1990

KEY

lip, trp, ster

CLA

coding, basic

LOC

11 q11

MIM

MIM: 167040