Gene: [05q1/HMGCR] 3-hydroxy-3-methylglutaryl-Coenzyme A reductase;

GEN

About HMGCR gene structure features, see in GEM:05p1/HMGCS1.

FUN

[1] The enzyme participates in mevalonic acid metabolism and biosynthesis of cholesterol and ubiquinone progenitors.
[2] Systematic name: (S)-mevalonate:NAD+ oxidoreductase (CoA-acylating). The reaction catalyzed: (S)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH."

FAG

See GEM:05p1/HMGCS1.

REF

EXP,MEB "Auwerx &: PNAS, 86, N4, 1133-1137, 1989
LOC,PRO "Henry I &: CCG, 40, (HGM8), 649-650, 1985
GEN,SEQ,LOC,PRO,POL "Humphries SE &: Hum Genet, 71, 254-258, 1985
PRO,POL,MUT "Leitersdorf E &: NAR, 18, 5584, 1990
LOC,PRO "Lindgren V &: PNAS, 82, N24, 8567-8571, 1985
GEN,STR,EXP,EVO "Luskey KL &: Mol Cell Biol, 7, 1881-1893, 1987
LOC,PRO "Mohandas T &: Somat Cell Mol Genet, 12, N1, 89-94, 1986
LOC,PRO "Mohandas T &: CCG, 40, (HGM8), 700-701, 1985

SWI

 SWISSPROT: P04035

KEY

lip

CLA

coding, basic

LOC

05 q13.3-14

MIM

 MIM: 142910

EZN

 ENZYME: 1.1.1.88

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