Gene: [05p12/PRKAA1] protein kinase, AMP-activated, alpha 1 catalytic subunit (AMPK alpha 1);
COM | The human AMPK-gamma-1 gene was mapped to 5p12 by fluorescence in situ hybridization (Stapleton-1997)." |
FUN | The 5-prime-AMP-activated protein kinase plays a key role in the regulation of fatty acid and cholesterol metabolism (Hardie-1992) and may be involved in regulation of intermediary metabolism and neuronal functions including learning and gene transcription in the nucleus. In vitro, it phosphorylates and inactivates 3-hydroxy-3-methylglutaryl-CoA reductase (GEM:05q1/HMGCR) and acetyl-CoA carboxylase (GEM:17q21/ACACA), key enzymes involved in regulating de novo biosynthesis of cholesterol and fatty acids, respectively." |
MOP | AMPK is a heterotrimeric protein composed of a catalytic alpha subunit (GEM:05p12/PRKAA1; GEM:01p31/PRKAA2), a noncatalytic beta subunit (GEM:12q24/PRKAB1; GEM:00.0/PRKAB2), and a noncatalytic gamma subunit (GEM:12q131/PRKAG1; GEM:00.0/PRKAG2)." |
REF | FUN,EXP,REV "Hardie
DG: BBA, 1123, N3, 231-238, 1992 LOC,FUN "Stapleton D &: FEBS Lett, 409, N3, 452-456, 1997 IDN,FAG "Stapleton D &: JBC, 271, 611-614, 1996 |
SWI | SWISSPROT: Q13131 |
KEY | lip, ats, pep |
CLA | coding, basic |
LOC | 05 p12 |
MIM | MIM: 602739 |
EZN | ENZYME: 2.7.1.? |
