Gene: [11q13/GSTP1] glutathione S-transferase pi (placental; EC:2.5.1.18); fatty acid ethyl ester synthase III, myocardial (EC:3.1.1.67);

GEN

 The gene length is 2.9 kb; exons:7; introns: 6 (Morrow-1989; Bora-1997).

FUN

 [1] Glutathione S-transferase participates in metabolism of various enogenous and exogenous hydrophobic substances. It has a wide substrate specifity.
[2] Systematic name: RX:glutathione R-transferase. Catalyzes reaction: RX + glutathione = HX + R-S-G."

TIS

 This glutathione transferase isoform is expressed in many organs and tissues, although it is sometimes referred to as a placental form."

HIS

 It was originally assumed that the gene that was mapped to Chr 11 is GST1; however, later it was demonstrated to be GST3."

FAG

 For more details on localization of GST genes and classification of their products, see FAM:GST/00.0."

PSG

 GEM:12q1/GSTPP.

REF

 SEQ,GEN,LOC "Bora PS &: Mol Cell Biochem, 173, 145-151, 1997
CLO,SEQ,STR,LOC "Bora PS &: Genomics, 19, 186-188, 1994a
POL "Bora PS &: Hum Mol Genet, 3, 2267, 1994b
CLO,SEQ "Bora PS &: JBC, 266, 16774-16777, 1991
EXP,ONT "Hiley &: BBA, 990, 321-324, 1989
CLO,GEN,SEQ,EVO "Morrow CS &: Gene, 75, N1, 3-11, 1989
LOC,CYG,LIN "Silberstein DL, Shows TB: Somat Cell Genet, 8, 667-675, 1982
LOC,MAP "Smith CM &: Genome Res, 7, N8, 835-842, 1997
LOC,CYG,LIN "Suzuki T, Board P: Somat Cell Mol Genet, 10, 319-320, 1984

KEY

 xen, lip

CLA

 coding, basic

LOC

 11 q13

MIM

 MIM: 134660

EZN

 ENZYME: 2.5.1.18

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