Gene: [01p133/GSTM1] glutathione S-transferase M1 (mu class; H-b; liver); lung cancer? (susceptibility, in smoker);

FUN

[1] Glutathione S-transferase participates in metabolism of various endogenous and exogenous hydrophobic substances. It has a wide specificity.
[2] Systematic name: RX:glutathione R-transferase. The catalyzed reaction: RX + glutathione = HX + R-S-G."

FAG

According to preliminary data (Islam-1989), a GST1-like gene is located in Chr 3 (GEM:03^/GSTM1L). However, it can not be ruled out that this is one of the unmapped functional genes coding for other glutathione transferase isoforms. For more details on the localization of GST genes and classification of their products, see FAM:GST/00.0."

HIS

Originally, the GSTM1/GST1 gene was thought to be located in Chr 11. However, Laisney-1983 and Suzuki-1984 demonstrated that it is actually GST3 (GEM:11q13/GSTP1) that is located there. GSTM1 has been mapped later to Chr 1p133."

REL

GEM:03^/GSTM1L; GEM:01p133/GSTM2; GEM:01p133/GSTM3; GEM:01p133/GSTM4; GEM:01p133/GSTM5."

REF

REV,FAG "Board PG &: BBA, 953, 214-217, 1988
MEB,FOG,EXP,FAG "Board PG, Webb: PNAS, 84, N8, 2377-2381, 1987
MEB,FOG,EXP,FAG "Board PG: AJHG, 33, 36-43, 1981a
REV "Board PG: AJHG, 33, 36-43, 1981b
REV,FAG "Chow NW &: JBC, 263, N26, 12797-12800, 1988
PRO,CYG,MOL,POL "DeJong JL &: CCG, 51, (HGM10), 986, 1989
LOC,SEQ,EXP "DeJong JL &: NAR, 16, 8541-8554, 1988
MEB,FOG,EXP,FAG "Harada &: Hum Genet, 75, 322-325, 1987
LOC,CYG,MOL,EXP "Islam MQ &: Hum Genet, 82, 338-342, 1989
REV "Laisney V &: Hum Genet, 68, N3, 221-227, 1984
LOC,CYG "Laisney V &: Ann Genet, 26, 69-74, 1983
SEQ,EVO "Mannervik B &: PNAS, 82, N21, 7202-7206, 1985a
REV "Mannervik B: Adv Enzymol Relat Areas Mol Biol, 57, 357-417, 1985b
MEB,FOG,EXP,FAG "Scott, Wright: AJHG, 32, 115-117, 1980
PAT,PAT,NOM "Seidegard J &: Carcinogenesis, 11, N1, 33-36, 1990
SEQ,POL,MUT,POP "Seidegard J &: PNAS, 85, N19, 7293-7297, 1988
PAT,PAT,NOM "Seidegard J &: Carcinogenesis, 7, N5, 751-753, 1986
LOC,CYG "Silberstein DL &: CCG, 32, (HGM6), 317, 1982a
LOC,CYG "Silberstein DL, Shows: Somat Cell Genet, 8, N5, 667-675, 1982b
MEB,FOG,EXP,FAG "Strange &: Biochem Genet, 23, 1011-1028, 1985
MEB,FOG,EXP,FAG "Strange &: Ann Hum Genet, 48, 11-20, 1984
MEB,FOG,EXP,FAG "Suzuki &: Ann Hum Genet, 51, 95-106, 1987
LOC,CYG "Suzuki, Board: Somat Cell Mol Genet, 10, N3, 319-320, 1984

SWI

 SWISSPROT: P09488

KEY

xen

CLA

coding, basic

LOC

01 p13.3

MIM

 MIM: 138350

EZN

 ENZYME: 2.5.1.18

Ссылки: