Gene: [12q13/WNT1] wingless-type MMTV integration site 1; murine mammary tumor virus integration site homolog 1; [INT1 ]
FUN | The Drosophila homolog of INT1/WNT1 is 'wingless,' a segment-polarity gene. Indirect evidence that WNT1 is secreted and that the product of 'wingless' is a diffusible gene product suggests that these proteins are secreted growth factors." |
FAG | Twelve human homologues for murine mammary tumor virus integration sites (MMTV) were found. They are potential protooncogenes (WNT1; GEM:07q31/WNT2; GEM:01p13/WNT2B; GEM:17q21/WNT3; GEM:03p/WNT5A; GEM:03p25/WNT7A; GEM:22q133/WNT7B; GEM:00.0/WNT8A; GEM:10q24/WNT8B; GEM:12q131/WNT10B; GEM:01^/WNT14; GEM:17q21/WNT15). WNT genes encode intercellular signaling glycoproteins that play important roles in key processes of embryonic development." |
REF | LOC "Arheden K &: CCG,
47, 86-87, 1988 FUN "Fujii Y &: Jpn J Cancer Res, 80, 958-962, 1989 REV,EVO,FUN,MOU "McMahon AP: Trends Genet, 8, 236-242, 1992 NOM "Nusse R &: Cell, 64, 231, 1991 PRO,LOC,MOL "Nusse R &: CCG, 37, (HGM7), 556-557, 1984 FUN "Thomas KR, Capecchi MR: Nature, 346, 847-850, 1990 LOC "Turc-Carel C &: CCG, 46, 706, 1987a LOC "Turc-Carel C &: Oncogene Res, 1, 397-405, 1987b PRO,LOC,MOL "van't Veer LJ &: Mol Cell Biol, 4, 2532-2534, 1984 |
SWI | SWISSPROT: P04628 |
KEY | onc, ont |
CLA | coding, basic |
LOC | 12 q13 |
MIM | MIM: 164820 |
SYN | INT1 |
