Gene: [12q242/NOS1] nitric oxide synthase 1 (neuronal);

FUN

The nitric oxide is suggested to be a physiologic mediator of erectile function in rat (Burnett-1992). NOS may be responsible for the synthesis of nitric oxide during penile erection and may be involved in control of the tone of the urethra, prostate, and bladder (Magee-1996). The exact function of human NOS2A is unknown."

REL

GEM:17q1/NOS2A; GEM:17^/NOS2B; GEM:17^/NOS2C; GEM:07q36/NOS3.

REF

CLO,EXP "Bredt DS &: Nature, 351, 714-718, 1991
RAT,FUN "Burnett AL &: Science, 257, 401-403, 1992
CLO,LOC "Kishimoto J &: Genomics, 14, 802-804, 1992
RAT,FUN,EXP "Magee T &: BBRC, 226, 145-151, 1996
CLO,LOC "Marsden PA &: JBC, 268, 17478-17488, 1993
SEQ,EXP,GEN "Xie J &: PNAS, 92, 1242-1246, 1995
CLO,LOC "Xu W &: CCG, 64, 62-63, 1993

SWI

SWISSPROT: P29475

KEY

neu

CLA

coding, basic

LOC

12 q24.2

MIM

MIM: 163731

EZN

ENZYME: 1.14.13.39

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