Gene: [15q22/PRKMK1] protein kinase, mitogen-activated, kinase 1 (43.5kD); MAP kinase kinase 1 (MAPKK 1);
FUN | [1] The
general function of mitogen-activated protein kinase (MAPK) cascades is to
relay environmental signals to the transcriptional machinery in the nucleus
and thus modulate gene expression. MAPK cascades consist of a 3-kinase
module composed of an MAPK (or PRKM, e.g. GEM:22q112/PRKM1), an MAPK kinase (MAPKK, or
PRKMK), and an MAPKK kinase (MAPKKK, or MEKK, e.g. GEM:05^/MEKK1). Specific PRKMKs have been shown to
phosphorylate specific PRKMs in a given module. [2] At least 3 distinct MAPK cascades exist in mammals: one leads to the activation of the extracellular signal-regulated kinases (ERKs; e.g., GEM:16p112/PRKM3); another leads to the activation of the p38s (e.g., GEM:00.0/PRKM11); and a third leads to the activation of the c-jun N-terminal kinases (JNKs; see on them in GEM:10^/PRKM8)." |
FAG | The other PRKMK genes have been found: GEM:00.0/PRKMK2; GEM:17q112/PRKMK3; GEM:17p112/SERK1(PRKMK4); GEM:00.0/PRKMK5; GEM:00.0/PRKMK6; GEM:00.0/PRKMK7." |
REF | LOC "Rampoldi L &:
CCG, 78, N3-4, 301-303, 1997 REV,FUN "Seger R, Krebs EG: FASEB J, 9, N9, 726-735, 1995 CLO,SEQ "Seger R &: JBC, 267, 25628-25631, 1992 CLO,SEQ "Zheng CF, Guan K &: JBC, 268, 11435-11439, 1993 |
SWI | SWISSPROT: Q02750 |
KEY | pep, sign |
CLA | coding, basic |
LOC | 15 q22.1-.33 |
MIM | MIM: 176872 |
EZN | ENZYME: 2.7.1.? |
