Gene: [22q112/PRKM1] protein kinase, mitogen-activated 1; MAP kinase 1 (p40, p41); extracellular signal-regulated kinase 2 (p42);
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FAG |
[1] Mitogen-activated protein kinases (PRKMs, or MAPKs) are
serine-threonine protein
kinases that are activated in response to a wide variety of extracellular
stimuli. They are part of complex protein kinase cascades.
MAPKs are activated by dual-specificity MAPK kinases (MAPKKs; see
GEM:05^/MEKK1; GEM:06^/MEKK4).
[2] The following genes coding for MAPKs have been found: GEM:22q112/PRKM1; GEM:16p112/PRKM3; GEM:18q/PRKM4; GEM:15q21/PRKM6; GEM:00.0/PRKM7; GEM:10^/PRKM8; GEM:05q35/PRKM9; GEM:21q21/PRKM10; GEM:00.0/PRKM11; GEM:22q133/SAPK3(PRKM12); GEM:00.0/PRKM13; GEM:06p21/CSBP(PRKM14,PRKM15)." |
|
REL |
GEM:03q/MYLK. See also GEM:15q22/PRKMK1; GEM:17p112/SERK1." |
|
REF |
CLO,SEQ "Gonzalez F &: FEBS Lett, 304, 170-178, 1992 LOC "Li L &: Oncogene, 9, 647-649, 1994 CLO,SEQ "Owaki H &: BBRC, 182, 1416-1422, 1992 |
|
KEY |
pep, sign |
|
CLA |
coding, basic |
|
LOC |
22 q11.2 |
|
MIM |
MIM: 176948 |
|
EZN |
ENZYME: 2.7.1.? |
