Gene: [15q2/CYP1A1] cytochrome P450, subfamily IA (aromatic compound-inducible) polypeptide 1; dioxin-inducible P1-450 (TCDD-inducible; P1-450);

GEN

The gene length is 6.3 kb. Exons: 7 (90, 851, 127, 90, 124, 87, and 1227 bp); introns: 6 (2644, 556, 87, 91, 145, and 192 bp); 5'-UNTR= 1604 bp, 3'-UNTR= 113 bp."

FUN

Dioxin-inducible cytochrome P450 participates in oxidation of many xenobiotics and in activation of procarcinogens."

FAG

On CYP superfamily genes, see FAM:CYP/00.0.

REF

PRO,SEQ,EXP "Chen &: Clin Res, 31, 456A, 1983
LOC,LIN,MOL "Hildebrand CE &: NAR, 13, 2009-2016, 1985
GEN,SEQ,EXP "Hines &: Carcinogenesis, 9, N9, 1599-1605, 1988
PRO,ENG,EXP "Jaiswal AK &: BBRC, 148, N2, 857-863, 1987a
PRO,GEN,SEQ "Jaiswal AK &: Mol Endocrinol, 1, 312-320, 1987b
LOC,LIN,MOL "Jaiswal AK, Nebert: NAR, 14, 4376, 1986
PRO,GEN,SEQ "Jaiswal AK &: NAR, 13, N12, 4503-4520, 1985a
PRO,SEQ,EXP "Jaiswal AK &: Science, 228, 80-83, 1985b
PRO,EXP,LIN,FOG,POL "Petersen DD &: AJHG, 48, 720-725, 1991
PRO,SEQ,EXP "Quattrochi LC &: DNA, 4, 395-400, 1985

SWI

 SWISSPROT: P04798

KEY

xen, onc

CLA

coding, basic

LOC

15 q22-24

MIM

 MIM: 108330

EZN

 ENZYME: 1.14.14.1

Ссылки: