Gene: [16p121/ITGAX] integrin, alpha X (CD11C; p150,95-alpha); antigen CD11C (alpha X integrin; LeuM5); [CD11C LEUM5 ]

GEN

The mature transcript (4.7 kb) codes for the signal peptide, the extracellular region (1081 amino acids) with 10 potential glycosilation sites, the transmembrane domain (26 amino acids), and the cytoplasmic C-terminal domain (29 amino acids)."

FUN

Receptor for leukocyte adhesion proteins.

MOP

The product of this gene (MM 130-150 kD) is a constituent of the protein p150,95. It noncovalently associates with the light beta subunit (beta-2 integrin; GEM:21q223/ITGB2), which can also associate with alpha subunits of two other leucocyte membrane surface proteins - complement 3 component (GEM:16p112/ITGAM) and protein LFA-1 (GEM:16p123/ITGAL)."

FAG

See FAM:ITG/00.0.

REF

LOC,FAG,PRO,SEQ "Corbi AL &: J Exp Med, 167, (May), 1597-1607, 1988
PRO,SEQ "Corbi AL &: EMBO J, 6, 4023-4028, 1987
FUN,EXP "Soligo &: Eur J Haematol, 42, 173-181, 1989

SWI

SWISSPROT: P20702

KEY

recp, imm, mem

CLA

coding, basic

LOC

16 p12.1

MIM

MIM: 151510

SYN

CD11C LEUM5

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