Gene: [16p121/ITGAX] integrin, alpha X (CD11C; p150,95-alpha); antigen CD11C (alpha X integrin; LeuM5); [CD11C LEUM5 ]
GEN | The mature transcript (4.7 kb) codes for the signal peptide, the extracellular region (1081 amino acids) with 10 potential glycosilation sites, the transmembrane domain (26 amino acids), and the cytoplasmic C-terminal domain (29 amino acids)." |
FUN | Receptor for leukocyte adhesion proteins. |
MOP | The product of this gene (MM 130-150 kD) is a constituent of the protein p150,95. It noncovalently associates with the light beta subunit (beta-2 integrin; GEM:21q223/ITGB2), which can also associate with alpha subunits of two other leucocyte membrane surface proteins - complement 3 component (GEM:16p112/ITGAM) and protein LFA-1 (GEM:16p123/ITGAL)." |
FAG | See FAM:ITG/00.0. |
REF | LOC,FAG,PRO,SEQ "Corbi AL &: J Exp Med, 167, (May), 1597-1607,
1988 PRO,SEQ "Corbi AL &: EMBO J, 6, 4023-4028, 1987 FUN,EXP "Soligo &: Eur J Haematol, 42, 173-181, 1989 |
SWI | SWISSPROT: P20702 |
KEY | recp, imm, mem |
CLA | coding, basic |
LOC | 16 p12.1 |
MIM | MIM: 151510 |
SYN | CD11C LEUM5 |
