Gene: [21q223/ITGB2] integrin, beta 2 (antigen CD18B (p95); LFA1-beta; LCAM-B); cell adhesion molecule, leukocyte, beta (light chain; LCAM-B); lymphocyte function-associated antigen 1, beta subunit (LCAM-B); complement component receptor 3, beta (beta 2 integrin; CD18; LCAM-B); immunodeficiency LFA1-beta (leukocyte adhesion deficiency; MIM:116920); [CD18 GP90 ]

FUN

Beta-2 integrin determines the adhesive properties of leukocyte cell surface."

MOP

Beta-2 integrin (94 kD) is a component of three leukocyte glycoproteins, which function is cell adhesion. These are: complement component receptor 3 (Mac-1; GEM:16p112/ITGAM), protein p150,95 (GEM:16p121/ITGAX), and LFA1-alpha (GEM:16p123/ITGAL). The three proteins differ in alpha subunits, which are noncovalently bound (one to three molecules) to beta-2 integrin and assigned to alpha integrins."

PAT

Beta-2 integrin deficiency (identified by the coincident deficiency of three glycoprotein complexes, LFA-1, Mac-1 (CR3), and p150,95) manifest itself as recurrent bacterial and fungous infections. At least five recessive variants of leukocyte adhesion defects, accounted for by mutant beta peptide inability to associate with alpha peptides, have been identified."

PRO

Probe J-9 contains a 2.8 kb cDNA insert; the clone has been obtained by scrinning U937 library, activated with phorbol ether."

FAG

See FAM:ITG/00.0.

REF

LOC,CYG "Akao &: CCG, 46, (HGM9), 568, 1987a
LOC,CYG "Akao &: Somat Cell Mol Genet, 13, 273-278, 1987b
REV,PAT "Anderson, Springer: Annu Rev Med, 38, 175-194, 1987
REV,PAT "Anderson &: J Infect Dis, 152, 668-689, 1985
MUT "Back AL &: BBRC, 193, 912-918, 1993
MUT "Back AL &: JBC, 267, N8, 5482-5487, 1992
PAT,TER,ENG "Hibbs ML &: J Clin Invest, 85, 674-681, 1990
REV "Hynes RO: Cell, 69, 11-25, 1992
FAG,PAT,SEQ "Kishimoto TK &: Cell, 48, 681-690, 1987a
MUT,PAT "Kishimoto TK &: Cell, 50, 193-202, 1987b
PAT,TER,MOD "Krauss &: J Clin Invest, 88, 1412-1417, 1991
PRO,SEQ "Law SKA &: EMBO J, 6, 915-919, 1987
LOC,CYG "Marlin SD &: J Exp Med, 164, 855-867, 1986
MUT "Matsuura S &: BBRC, 184, 1460-1467, 1992
MUT "Nelson C &: JBC, 267, 3351-3357, 1992
LOC,LIN,MAP "Petersen MB &: Genomics, 9, 407-419, 1991
LOC,LIN,MAP "Petersen MB &: CCG, 51, (HGM10), 1059, 1989
PAT "Rivera-Matos IR &: J Pediatr, 127, 755-757, 1995
FUN "Rosmarin AG &: PNAS, 92, 801-805, 1995
LOC,PRO "Solomon &: Ann Hum Genet, 52, 123-128, 1988
LOC,PRO,POL "Stewart &: AJHG, 43, A160, 1988
LOC,CYG "Suomalainen HA &: Somat Cell Mol Genet, 12, N3, 297-302, 1986
GEN "Weitzman &: FEBS Lett, 294, 98-103, 1991
PAT,TER,ENG "Wilson &: Science, 248, 1413-1416, 1990

SWI

SWISSPROT: P05107

KEY

imm, ont, mem, comp, recp

CLA

coding, basic

LOC

21 q22.3

MIM

MIM: 600065

SYN

CD18 GP90

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