Gene: [17q1/APLB] acute promyelocytic leukemia breakpoint on chr 17;

COM

 According to the international classification (FAB systematics - rench- merican-ritish Cooperative Group, Bennett-1976), this type of acute myelogenous leukemia (OML) is denoted as M3. It was demonstrated (Rowley-1977) that in almost all OML-M3 patients at the stage of promyelocytic crisis, the leukemic cells bear the chromosomal translocation involving long arms of chrs 17 and 15: t(15;17)(q22;q11.2-12)."

FAG

 Moore-1989 found a cluster of about 30 copies of a 18 kb nucleotide sequence in the region of APL-translocation breakpoint in chr 17. This cluster seems to be specific for chr 17. The revealed DNA repeats are scattered over 2 Mb region on both sides of the APL-breakpoint (for more details on these repeats, see GEM:17q1/D17Z2A)."

REF

 COM,PAT,NOM "Bennett &: Brit J Haematol, 33, 451-458, 1976
LOC,MOL,MAF,PRO "Moore G &: Genomics, 4, N2, 152-161, 1989
LOC,MOL,MAF,PRO "Rider &: CCG, 51, (HGM10), 1066, 1989
IDN,CYG,MAP "Rowley &: Int J Cancer, 20, 869-872, 1977

KEY

 onc, mgm

CLA

 unknown, basic

LOC

 17 q11.2-12

MIM

 ?

Ссылки: