Gene: [17q21/HCRT] hypocretin (orexin) neuropeptide precursor; [PPOX ]
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EXP |
Two neuropeptides orexin A (hypocretin 1) and orexin B (hypocretin 2) are derived from the same precursor (preproorexin) by proteolytic processing. The orexin receptor 1 (GEM:01p33/HCRTR1) binds orexin A only, whereas orexin receptor 2 (GEM:06^/HCRTR2) binds both orexin A and orexin B." |
|
REF |
CLO,MOU "de Lecea L &: PNAS, 95, N1, 322-327, 1998 CLO,SEQ,EXP,LOC,EVO "Sakurai T &: Cell, 92, N4, 573-585, 1998 |
|
KEY |
neu |
|
CLA |
coding, basic |
|
LOC |
17 q21 |
|
MIM |
MIM: 602358 |
|
SYN |
PPOX |
