Gene: [17q2/TOP2A] topoisomerase (DNA) II alpha (170kD);

EVO

The enzyme is analagous to bacterial DNA gyrase.

FAG

Gene for DNA topoisomerase I is mapped to the long arm of Chr 20: GEM:20q1/TOP1. Gene for DNA beta topoisomerase II is mapped to Chr 3: GEM:03p24/TOP2B."

REF

REV,FUN,MOP "Austin CA, Fisher LM: Science Progress, 74, N294 (Part 2), 147-162, 1990
MUT "Campain J &: Biochemistry, 33, N37, 11327-11332, 1994
CLO,SEQ,GEN "Loflin PT &: BBRC, 200, N1, 489-496, 1994
LOC "Tan KB &: Cancer Res, 52, N1, 231-234, 1992
PRO,SEQ,LOC "Tsai-Pflugfelder M &: PNAS, 85, N19, 7177-7181, 1988

KEY

repr, chr

CLA

coding, basic

LOC

17 q21-22

MIM

MIM: 126430

EZN

ENZYME: 5.99.1.3

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