Gene: [19p132/PRKCSH] protein kinase C substrate 80K-H (glycoprotein 80K-H); [PKCSH G19P1 ]
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MOP |
Acidic proteins with MM 80 kD are preferrable substrates of Ca, phospholipide-dependent protein kinase (protein kinase C). The study conducted on Ca9-22 cells obtained from human squamous cell carcinoma revealed two such proteins - 80K-H (heavy) and 80K-L (light). The amino acid sequence of the 80K-H protein was determined (it appeared to be glutamate-rich). cDNA probe for this protein was found, with the aid of synthesized DNA probe; and its gene was mapped to chr 19 (Minoshima-1989; Sakai-1989)." |
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FAG |
The gene for 80K-L protein is identified: GEM:06q2/PRKCSL. |
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REF |
CLO,COD,LOC,MOL "Minoshima &: CCG, 51, (HGM10), 1045, 1989 CLO,COD,SEQ,LOC,PEP "Sakai K &: Genomics, 5, 309-315, 1989 |
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KEY |
hem, serp |
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CLA |
coding, basic |
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LOC |
19 p13.2 |
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MIM |
MIM: 177060 |
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SYN |
PKCSH G19P1 |
