Gene: [19q132/BCL3] B-cell chronic lymphatic leukemia 3 (B-CLL: lymphoma 3); [BCL4 D19S37 ]
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COM |
Previously BCL3 locus was mapped (McKeithan-1987) with the aid of somatic hybrid cells and gDNA probe p-alpha.5B (a 0.5 kb fragment cloned at BamHI site), which is specific for a DNA sequence tightly linked to BCL3. Afterwards, this sequence was found to be located 16 kb closer to the centromere than the site of hybridization with BCL3-specific probe p-alpha-1.4B (Korneluk-1989a)." |
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PRO |
Probe name: Vector Site Insert (kb) Reference
[1] p-alpha-1.4P: bluescribe PstI 1.4 Korneluk-1989" |
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POL |
Enzyme Alleles in kb/(Popul Freq) (Reference; Probe
number)
[1] EcoRI+MluI A1= 9.0/(0.60); A2= 8.0/(0.40) (Harley-1989; Probe [1]): [2] BanI B1= 3.0/(0.82); B2= 2.2/(0.18) (Harley-1989; MacKenzie-1989; Korneluk-1989; Probe 1; const bands abs) [3] KpnI C1= 15.0/(?); C2= 4.0/(?) (Korneluk-1989; Probe [1])" |
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MAP |
Loci: GEM:19q134/PRKCG; GEM:19q132/CYP2A6; GEM:19q132/ATP1A3;
GEM:19q132/APOC1; GEM:19q132/APOC2; GEM:19q133/CKM; GEM:19q133/DMPK.
[1] See GEM:19q134/PRKCG. [2] c-D19S8-D19S16-BCL3-APOC2-CKM-DMPK-D19S50-D19S22-qt (MacKenzie-1989)." |
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REF |
COM,FAG "Gauwerky CE &: PNAS, 86, N22, 8867-8871, 1989 LOC,POL,MAP "Harley &: CCG, 51, (HGM10), 1011, 1989 PRO,LOC,MOL,POL,LIN,MAP "Korneluk RG &: Genomics, 4, N2, 146-151, 1989a POL,MOL "Korneluk RG &: NAR, 17, N14, 5874, 1989b POL,MOL "Korneluk RG &: NAR, 17, N14, 5875, 1989c LOC,POL,MAP "MacKenzie TW &: CCG, 51, (HGM10), 1036-1037, 1989 PRO,LOC,LIN "McKeithan TW &: PNAS, 84, N24, 9257-9260, 1987 LOC,LIN,MAP "Roses &: CCG, 51, (HGM10), 1069, 1989 LOC,POL,MAP "Shaw DJ &: Hum Genet, 83, N1, 71-74, 1989 LOC,CYG "Ueshima Y &: Int J Cancer, 36, 287-290, 1985 |
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KEY |
onc, imm, hem |
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CLA |
coding, basic |
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LOC |
19 q13.2 |
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MIM |
MIM: 109560 |
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SYN |
BCL4 D19S37 |
