Gene: [18q2133/BCL2] transforming protein BCL-2; B-cell chronic lymphatic leukemia 2 (B-CLL: lymphoma 2);

FUN

Blocks apoptosis. Adenilate cyclase modulator? (Haldar-1989).

HIS

BCL3 gene (located in 18q21) was previously considered to be a part of gene BCL2. However as early as in HGM10, this name was assigned to the gene in the long arm of chr 19, which was previously referred to as BCL4 (see GEM:19q132/BCL3)."

FAG

According to Haldar-1989, the product of this gene belong to the group of so called G proteins or adenylate cyclase modulators (see FAM:GNBP/00.0)."

REL

GEM:15^/BCL2A1; GEM:00.0/BCL2L1; GEM:14q1/BCL2L2.

REF

GEN,MUT "Aisenberg &: Blood, 71, N4, 969-972, 1988
GEN,MUT "Amakawa &: Blood, 73, N3, 787-791, 1989
GEN,MUT "Bakhshi A &: PNAS, 84, N8, 2396-2400, 1987
SEQ,EXP "Cleary &: Cell, 47, 19-28, 1987
LOC "Cleary &: J Exp Med, 164, 315-320, 1986
SEQ,EXP "Cleary &: PNAS, 82, N21, 7439-7443, 1985
GEN,MUT "Cotter &: Blood, 73, N5, 1387-1388, 1989
IDN,FUN "Haldar S &: Nature, 342, N6246, 195-198, 1989
MUT "Komaki &: Hum Genet, 103, 435, 1998
EXP,PAT,TIS "Mariano &: Blood, 80, N3, 768-777, 1992
GEN,MUT "Ngan &: Blood, 73, N7, 1759-1762, 1989
EXP,PAT "Ngan &: New Engl J Med, 318, N25, 1638-1644, 1988
GEN,MUT "Tsujimoto Y &: PNAS, 84, N5, 1329-1331, 1987
SEQ,PEP "Tsujimoto Y, Groce: PNAS, 83, N14, 5214-5218, 1986
PRO,LOC "Tsujimoto Y &: Nature, 315, 340-343, 1985a
PRO,LOC "Tsujimoto Y &: Science, 228, 1440-1443, 1985b
PRO,LOC "Tsujimoto Y &: Science, 229, 1390-1393, 1985c
PRO,LOC "Tsujimoto Y &: Science, 226, 1097-1099, 1984

SWI

 SWISSPROT: P10415

KEY

onc, imm, hem

CLA

coding, basic

LOC

18 q21.33

MIM

 MIM: 151430

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