Gene: [19q13/KLK1] kallikrein 1 (renal/pancreas/salivary);

COM

The product of previously mapped to Chr 19q ARS gene (prostata-specific antigen) was demonstrated to contain kallikrein-like domains and to show the proteolytic activity. Therefore it is registered in the HUGEN as a kallikrein-like protease, see GEM:19q133/KLKPS."

FAG

[1] Genes KLK1, KLK2 (GEM:19q133/KLK2), KLKPS, and KLK3 (GEM:04q35/KLK3) belong to the serine proteinase multigene superfamily."

POL

Polymorphism with respect to MspI restriction fragments is found (Hermens-1990)."

REF

LOC,GEN,EAG "Evans BA &: Biochemistry, 27, 3124-3129, 1988
PRO,POL "Hermens R &: NAR, 18, N1, 208, 1990
LOC,LIN,MAP "Schonk D &: CCG, 51, (HGM10), 1075, 1989a
LOC,LIN,MAP "Schonk D &: Genomics, 4, N3, 384-396, 1989b

KEY

pep, horm

CLA

coding, basic

LOC

19 q13.3-.4

MIM

MIM: 147910

EZN

ENZYME: 3.4.21.35

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