Gene: [20q131/YWHAB] tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide (phosphorylated); brain protein 14-3-3, beta subtype (phosphorylated alpha subtype included); [YWHAA ]

COM

[1] Previously considered a distinctive member of the 14-3-3 family, the alpha isoform is now included in the beta subtype as the post-transla- tionally phosphorylated product of the latter (Aitken-1995).
[2] For general information about this protein family, see 'Summary' in FAM:BP1433/00.0"

COD

"<* ="<*" sources="BR" title="{PRT="><** h="/ID:" mol="%-----------------------------------------------------------------------<*** cited="[EMBL] /ID: emb:X57346^HS1054RNA| cDNA= 1213 bp;
'Homo sapiens mRNA for HS1 protein (clone 1054)';
//note: from SV40 transformed MRC-5 fibroblasts (MRC-5 V2)\
/Date: Jul-19-1993\
/Submitted_by: Leffers H (Univ of Aahrus, Inst of Medical Biochemistry,
Universitetsparken Bygn 170, DK 8000 Aahrus C, Denmark);
//date: Jan-23-1991\
/Duplicated_by: cbi:23113-114\
/Note: The original author remark is as follows:'the protein is related
to the protein kinase C inhibitory protein (KCIP) and protein 14-3-3,
an activator of tyrosine and tryptophan hydroxylases; is expressed
in all the tissues being assayed'\
%-----------------------------------------------------------------------
<*** cited="[PROT_DB]<**** record="[SwissPROT] /ID: swp:P31946^143B_HUMAN| prt= 244 aa (MW= ?);
'14-3-3 protein beta (protein kinase C inhibitor protein-1,
KCIP-1; protein 1054)'\
/Date: Jul-01-1993^Feb-01-1994\
/Duplicated_by: cbi:398954\
/Note_1: There is a confusing remark, in this swp:record:[the protein]
'STRONGLY ACTIVATES protein kinase C'; it is inconsistent with a
definition presented above (see the title of the swp:record\
/Note_2: This AA-sequence lacks the first two residues (Met/M and Thr/
T) presented in the other two versions of the sequence; features
indicated in this swp:record probably need to be corrected\
/Features: total= 1..244 //note: 14-3-3 protein beta;
site= 1 //note: acetylation (putative);
site= 58 //note: phosphorylation (putative);
site= 63 //note: phosphorylation (putative)\
<**** record="[PIR] /ID: pir:S34755| prt= 246 aa (MW= 28082);
'14-3-3 protein (clone 1054) - human'\
/Date: Dec-31-1993 & May-03-1994\
/Duplicated_by: cbi:486668\
%-----------------------------------------------------------------------
<* features="BR"><** note="BR"> /Note_1: UTL - UnTransLated segment; CDS - CoDing Segment;
TLI - TransLation Initiation; TLT - TransLation Termination;
TTS - Transcription Termination Signal (polyA-signal);
TCT - TransCription Termination site (polyA-site);
pAseq - polyA-sequence\
/Note_2: The following 'Landmarks' and 'Sequence' are derived from
'ref1:' Leffers H &:1993 (emb:X57346)\
<** landmarks="BR"> {seg(1..372) = 5'-UTL(=372);
seg(373..1110) = CDS(=738) //note: for 246 amino acids;
pos:373 = TLI_1 //note: <_atg> translation START;
seg(1111..1213) = 3'-UTL(=103);
pos:1111 = TLT_1 //note: <_taa> translation STOP;
pos:? = TTS_? //note: not described;
pos:1179? = TCT_1? //note: polyA-site;
seg(1180..1213) = pAseq}
%-----------------------------------------------------------------------
<* ="%-------- ref1: 1=taccgccacc gccgccgccg attccggagc cggggtagtc gccgccgccg=
ref1: 51=ccgccgccgc tgcagccact gcaggcaccg ctgccgccgc ctgagtagtg=
ref1: 101=taccgccacc gccgccgccg attccggagc cggggtagtc gccgccgccg=
ref1: 151=ccgccgccgc tgcagccact gcaggcaccg ctgccgccgc ctgagtagtg=
ref1: 201=ggcttaggaa ggaagaggtc atctcgctcg gagcttcgct cggaagggtc=
ref1: 251=tttgttccct gcagccctcc cacggcagag tctccagaga tttgggccgc=
ref1: 301=tacaaaaagt gcattttgcc cattcggctg tggatagaga agcaggaaga=
ref1: 351=gcactggact tggagtcagg ga=372_
%--------
<** ="%-------- pep: 1= M T M D K S E L V Q K A K L A =
ref1: 373=atg aca atg gat aaa agt gag ctg gta cag aaa gcc aaa ctc gct=
pep: 16= E Q A E R Y D D M A A A M K A =
ref1: 418=gag cag gct gag cgc tat gat gat atg gct gca gcc atg aag gca=
pep: 31= V T E Q G H E L S N E E R N L =
ref1: 463=gtc aca gaa cag ggg cat gaa ctc tcc aac gaa gag aga aat ctg=
pep: 46= L S V A Y K N V V G A R R S S =
ref1: 508=ctc tct gtt gcc tac aag aat gtg gta ggc gcc cgc cgc tct tcc=
pep: 61= W R V I S S I E Q K T E R N E =
ref1: 553=tgg cgt gtc atc tcc agc att gag cag aaa aca gag agg aat gag=
pep: 76= K K Q Q M G K E Y R E K I E A =
ref1: 598=aag aag cag cag atg ggc aaa gag tac cgt gag aag ata gag gca=
pep: 91= E L Q D I C N D V L E L L D K =
ref1: 643=gaa ctg cag gac atc tgc aat gat gtt ctg gag ctg ttg gac aaa=
pep:106= Y L I P N A T Q P E S K V F Y =
ref1: 688=tat ctt att ccc aat gct aca caa cca gaa agt aag gtg ttc tac=
pep:121= L K M K G D Y F R Y L S E V A =
ref1: 733=ttg aaa atg aaa gga gat tat ttt agg tat ctt tct gaa gtg gca=
pep:136= S G D N K Q T T V S N S Q Q A =
ref1: 778=tct gga gac aac aaa caa acc act gtg tcg aac tcc cag cag gct=
pep:151= Y Q E A F E I S K K E M Q P T =
ref1: 823=tac cag gaa gca ttt gaa att agt aag aaa gaa atg cag cct aca=
pep:166= H P I R L G L A L N F S V F Y =
ref1: 868=cac cca att cgt ctt ggt ctg gca cta aat ttc tca gtc ttt tac=
pep:181= Y E I L N S P E K A C S L A K =
ref1: 913=tat gag att cta aac tct cct gaa aag gcc tgt agc ctg gca aaa=
pep:196= T A F D E A I A E L D T L N E =
ref1: 958=acg gca ttt gat gaa gca att gct gaa ttg gat acg ctg aat gaa=
pep:211= E S Y K D S T L I M Q L L R D =
ref1:1003=gag tct tat aaa gac agc act ctg atc atg cag tta ctt agg gac=
pep:226= N L T L W T S E N Q G D E G D =
ref1:1048=aat ctc act ctg tgg aca tcg gaa aac cag gga gac gaa gga gac=
pep:241= A G E G E N =246\
ref1:1093=gct ggg gag gga gag aac=1110_
%--------
<** ="%-------- ref1:1111=TAAtgtttct cgtgctttgt gatctgtcca gtgtcactct gtaccctcaa=
ref1:1161=catatatccc ttgtgcgaT_aaaaaaaaaaa aaaaaaaaaa aaaaaaaaaa=
ref1:1211=aaa=1213\"

REL

GEM:17p13/YWHAE; GEM:00.0/YWHAG; GEM:22q12/YWHAH; GEM:00.0/BP1433TA; GEM:00.0/BP1433TH; GEM:02p25/YWHAZ."

ECR

"<* cross-references="[PROT_DB] /ID: swp:P31946^143B_HUMAN| prt= 244 aa /Date: Jul-01-1993^Feb-01-1994;
/Duplicated_by: cbi:398954\
/ID: pir:S34755...........| prt= 246 aa /Date: Dec-31-1993^May-03-1994;
/Duplicated_by: cbi:486668\
<* cross-references="[DNA_DB] /ID: emb:X57346^HS1054RNA| cDNA= 1213 bp /Date: Jul-19-1993;
/Duplicated_by: cbi:23113-114\"

REF

COM,SYS,PEP,PTM "Aitken A &: JBC, 270, N11 (Mar 17), 5706-5709, 1995
CLO,SEQ,COD,PEP,EXP "Leffers H &: J Mol Biol, 231, N4 (Jun 20), 982-998, 1993
LOC "Tommerup N, Leffers H: Genomics, 33, 149-150, 1996

SWI

 SWISSPROT: P31946

KEY

aac, sign, neu

CLA

coding, basic

LOC

20 q13.1

MIM

 MIM: 601289

SYN

YWHAA

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