Gene: [22q112/IGLVL1] immunoglobulin variable region related pre-B cell peptide 1; immunoglobulin lambda-like polypeptide 1; agammaglobulinaemia, autosomal recessive; [IGL5 VPREB1 ]
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SUM |
A IGLL1 gene formerly designated VPREB has been found to be highly conserved in many mammalian species (Kudo-1987; Bauer-1988). Its structure, which has been determined in mouse and man, shows regional homologies to variable regions of heavy and light chains of immunoglobulin." |
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HIS |
The report of Bauer-1988 leaves the relationship of this gene to the basic VAR minigene cluster (FAM:IGL/22q11) unclear." |
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REF |
PRO,LOC,MAF "Bauer SR &: Immunogenetics, 28, 328-333, 1988 LIN,MAF "Bauer TR &: Immunogenetics, 38, 387-399, 1993 LIN,MAF "Bossy D &: Int Immunol, 3, 1081-1090, 1991 MOU,EAG "Kudo A, Melchers F: EMBO J, 6, 2267-2272, 1987 LOC,FAG "Mattei M-G &: Genomics, 9, 544-546, 1991 MUT "Minegishi Y &: J Exp Med, 187, N1, 71-77, 1998 COD,EXP "Schiff C &: Eur J Immunol, 19, 1873-1878, 1989 |
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KEY |
imm, img |
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CLA |
coding, basic |
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LOC |
22 q11.2 |
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MIM |
MIM: 146770 |
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SYN |
IGL5 VPREB1 |
