Gene: [22q11/MN1] meningioma-associated protein MN1; meningioma chromosome region; [MGCR1 MGCR ]

COM

[1] Using a balanced translocation t(4;22), Lekanne Deprez-1995 isolated a gene they designated MN1 which was disrupted by the translocation.
[2] GDB points two loci for this gene: MGCR (GDB:G00-120-180) with location in Chr 22 q12.3-t (G00-120-180) and MGCR1-PEN (GDB:G00-580-528) with location in Chr 22 q11 (G00-580-528)."

GEN

Gene length: 70 kb (app.). Exons: 2 (app. 4.7 kb and 2.8 kb). The cDNA encodes a protein of 1,319 amino acids (Lekanne Deprez-1995)."

ASS

In sporadic meningiomas, it was found specific loss of expression of a beta-adaptin gene (GEM:22q12/ADTB1)."

MUT

The MN1 gene is fused to the ETV6 gene (GEM:12p13/ETV6) in the t(12;22), which is observed in some patients with acute myeloid leukemia (Buijs-1995)."

HIS

[1] In one meningioma case, the loss of homozygosity was found, however, it was observed in chr 3 (3q24-qt) rather than chr 22 (Farber-1991).
[2] MN1 gene is fused to the TEL gene (600618) in the t(12;22), which is observed in some patients with acute myeloid leukemia (Buijs-1995)."

REF

LOC,CYG "Arinami T &: J Med Genet, 23, 179-179, 1986
LOC,ABR,PAT "Buijs A &: Oncogene, 10, 1511-1519, 1995
LOC,CYG "Cogen &: CCG, 46, (HGM9), 595, 1987
LOC,CYG "Dumanski JP &: Cancer Res, 50, 5863-5867, 1990
LOC,CYG "Dumanski JP &: PNAS, 84, N24, 9275-9279, 1987
HIS,CAG "Farber U &: CCG, 57, N2-3, 157-158, 1991
PAT,FOG,CYG "Lekanne Deprez RH &: J Neuropath Exp Neurol, 54, 224-235, 1995a
CLO,COD,SEQ,LOC "Lekanne Deprez RH &: Oncogene, 10, 1521-1528, 1995b
ABR,LIN "Lekanne Deprez RH &: AJHG, 48, 783-790, 1991
LOC,CYG "Meese E &: Hum Genet, 77, 349-351, 1987
LOC,CYG "Seizinger BR &: PNAS, 84, N15, 5419-5423, 1987
LOC,CYG "Zang KD &: Cancer Genet Cytogenet, 6, 249-274, 1982

KEY

neu, onc

CLA

coding, basic

LOC

22 q11

MIM

MIM: 156100

SYN

MGCR1 MGCR

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