Gene: [12p13/ETV6] ets translocation variant gene 6 (TEL oncogene); [TEL ]

FAG

Tel oncogene fuses to the platelet-derived growth factor receptor beta gene (GEM:05q3/PDGFRB) in leukemias with (5;12) chromosomal translocation (Golub-1994); to the oncogene Aml1 (GEM:21q223/CBFA2) in acute myeloid leukemia with (12;21) chromosomal translocation (Golub-1995); and to the oncogene Abl1 (GEM:09q341/ABL1) in chronic myelogenous leukemia with (9;12) chromosomal translocation (Papadopoulos-1995, Janssen-1995)."

REL

See GEM:07p22/ETV1.

REF

CLO,SEQ,GEN "Baens M &: Genome Res, 6, N5, 404-413, 1996
ABR,LOC,PAT "Buijs A &: Oncogene, 10, 1511-1519, 1995
ABR,LOC,PAT "Golub TR &: PNAS, 92, 4917-4921, 1995
CLO,SEQ,ABR "Golub TR &: Cell, 77, 307-316, 1994
ABR,LOC,PAT "Janssen JWG &: Brit J Haematol, 90, N1, 222-224, 1995
ABR,LOC "Kobayashi H &: Blood, 84, 3473-3482, 1994
ABR,FUN "Lacronique V &: Science, 278, N5341, 1309-1312, 1997
ABR,LOC,PAT "Papadopoulos P &: Cancer Res, 55, 34-38, 1995
ABR,FUN "Peeters P &: Blood, 90, N7, 2535-2540, 1997
ABR,LOC,PAT "Stegmaier K &: Blood, 86, 38-44, 1995

SWI

SWISSPROT: P41212

KEY

trc

CLA

coding, basic

LOC

12 p13

MIM

MIM: 600618

SYN

TEL

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