Gene: [09q341/ABL1] Abelson murine leukemia viral oncogene homolog 1; protein tyrosine phosphokinase (oncogene ABL1); chronic myelogenous leukemia (CML; Ph'-oncomarker);

PAT

Ph+ chronic myelogenous leukemia is associated with the reciprocal t(9;22) translocation culminating in the production of the chimeric p210(bcr/abl) protein possessing elevated protein tyrosine kinase activity relative to the normal c-abl tyrosine kinase."

FAG

On the relationship of ABL1 with chronic myelogenous leukemia and Ph'-oncomarker (Philadelphia oncomarker resulted from the translocation <9q34;22q11>), see GEM:22q1122/BCR1."

REF

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SWI

SWISSPROT: P00519

KEY

onc, hem, ont

CLA

coding, basic

LOC

09 q34.1

MIM

MIM: 189980

EZN

ENZYME: 2.7.1.112

Ссылки: