Gene family: glutathione S-transferases; (GSTA1 GSTA2 GSTA3 GSTAP1 GSTAP2 GSTE GSTM1 GSTM1L GSTM2 GSTM3 GSTM4 GSTM5 GSTMS1 GSTMS2 GSTMS3 GSTP1 GSTPP GSTT1 GSTT2)
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FUN |
Glutathione transferase, being an enzyme of broad substrate specificity, participates in the metabolism of different xenobiotics." |
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PAT |
A relationship of the disturbance of liver isoform (GSTM1) function with the liability to lung cancer in smokers (Seidegard-1986), as well as the GSTA2 deficiency with congenital hyperbilirubinemia (Levi-1969; Board-1981b), were hypothesized." |
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FAG |
[1] Ten human glutathione transferase forms are characterized
biochemically and immunologically:
three liver forms: GSTA1, GSTA2, GSTM1;
the constitutive form, GSTP1 (it is expressed in different tissues,
although sometimes it is referred to as the placental form);
the muscle form, GSTM2;
the cerebral form, GSTM3;
the erythrocytic form, GSTE; and
the microsomal forms: GEM:12^/GSTMS1; GEM:04q/GSTMS2, GEM:00.0/GSTMS3.
[2] On the basis of phylogenetic comparisons, four GST peptide classes are distinguished: alpha (GSTA1, GSTA2, GSTA3), mu (GSTM1, GSTM2, GSTM3, GSTM4, GSTM5), pi (GSTP1), and theta (GSTT1, GSTT2). GSTE, GSTMS1, GSTMS2, and GSTMS3 are not classified yet." |
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REF |
REV,FAG "Board PG &: BBA, 953, 214-217, 1988 MEB,FOG,EXP,FAG "Board PG, Webb: PNAS, 84, N8, 2377-2381, 1987 MEB,FOG,EXP "Board PG: AJHG, 33, 36-43, 1981a PAT,MEB,LIN "Board PG: FEBS Lett, 135, 12-14, 1981b REV,MEB,FUN,EXP "Campbell EA: Einstein Quart J Biol Med, 8, N4, 106-115, 1990 REV,FAG "Chow NW &: JBC, 263, N26, 12797-12800, 1988 CLO,CYG,MOL,POL "DeJong JL &: CCG, 51, (HGM10), 986, 1989 LOC,FAG,EXP "DeJong JL &: NAR, 16, N17, 8541-8554, 1988 MEB,FOG,EXP,FAG "Harada &: Hum Genet, 75, 322-325, 1987 LOC,FAG,EXP "Islam MQ &: Hum Genet, 82, 338-342, 1989 REV "Laisney V &: Hum Genet, 68, N3, 221-227, 1984 LOC,CYG "Laisney V &: Ann Genet, 26, 69-74, 1983 PAT,MEB,LIN "Levi &: Lancet, 2, 139-140, 1969 REV "Mannervik B &: PNAS, 82, N21, 7202-7206, 1985a REV "Mannervik B: Adv Enzymol Relat Areas Mol Biol, 57, 357-417, 1985b MEB,FOG,EXP "Scott, Wright: AJHG, 32, 115-117, 1980 PAT,MEB,LIN "Seidegard &: Carcinogenesis, 7, 751-753, 1986 LOC,CYG "Silberstein DL &: CCG, 32, (HGM6), 317, 1982a LOC,CYG "Silberstein DL, Shows: Somat Cell Genet, 8, N5, 667-675, 1982b MEB,EXP,FAG "Strange &: BBA, 993, 186-190, 1989 MEB,FOG,EXP,FAG "Strange &: Biochem Genet, 23, 1011-1028, 1985 MEB,FOG,EXP,FAG "Strange &: Ann Hum Genet, 48, 11-20, 1984 MEB,FOG,EXP,FAG "Suzuki &: Ann Hum Genet, 51, 95-106, 1987 LOC,CYG "Suzuki, Board: Somat Cell Mol Genet, 10, N3, 319-320, 1984 |
