Рис. LDLR seq.
Нуклеотидная и аминокислотная последовательности
гена low density lipoprotein receptor (LDLR)
человека.
ATG GGG CCC TGG GGC TGG AAA TTG CGC TGG ACC GTC GCC TTG CTC
met gly pro trp gly trp lys leu arg trp thr val ala leu leu 15
CTC GCC GCG GCG GGG ACT GCA GTG GGC GAC AGA TGT GAA AGA AAC
leu ala ala ala gly thr ala val gly asp arg cys glu arg asn 30
GAG TTC CAG TGC CAA GAC GGG AAA TGC ATC TCC TAC AAG TGG GTC
glu phe gln cys gln asp gly lys cys ile ser tyr lys trp val 45
TGC GAT GGC AGC GCT GAG TGC CAG GAT GGC TCT GAT GAG TCC CAG
cys asp gly ser ala glu cys gln asp gly ser asp glu ser gln 60
GAG ACG TGC TTG TCT GTC ACC TGC AAA TCC GGG GAC TTC AGC TGT
glu thr cys leu ser val thr cys lys ser gly asp phe ser cys 75
GGG GGC CGT GTC AAC CGC TGC ATT CCT CAG TTC TGG AGG TGC GAT
gly gly arg val asn arg cys ile pro gln phe trp arg cys asp 90
GGC CAA GTG GAC TGC GAC AAC GGC TCA GAC GAG CAA GGC TGT CCC
gly gln val asp cys asp asn gly ser asp glu gln gly cys pro 105
CCC AAG ACG TGC TCC CAG GAC GAG TTT CGC TGC CAC GAT GGG AAG
pro lys thr cys ser gln asp glu phe arg cys his asp gly lys 120
TGC ATC TCT CGG CAG TTC GTC TGT GAC TCA GAC CGG GAC TGC TTG
cys ile ser arg gln phe val cys asp ser asp arg asp cys leu 135
GAC GGC TCA GAC GAG GCC TCC TGC CCG GTG CTC ACC TGT GGT CCC
asp gly ser asp glu ala ser cys pro val leu thr cys gly pro 150
GCC AGC TTC CAG TGC AAC AGC TCC ACC TGC ATC CCC CAG CTG TGG
ala ser phe gln cys asn ser ser thr cys ile pro gln leu trp 165
GCC TGC GAC AAC GAC CCC GAC TGC GAA GAT GGC TCG GAT GAG TGG
ala cys asp asn asp pro asp cys glu asp gly ser asp glu trp 180
CCG CAG CGC TGT AGG GGT CTT TAC GTG TTC CAA GGG GAC AGT AGC
pro gln arg cys arg gly leu tyr val phe gln gly asp ser ser 195
CCC TGC TCG GCC TTC GAG TTC CAC TGC CTA AGT GGC GAG TGC ATC
pro cys ser ala phe glu phe his cys leu ser gly glu cys ile 210
CAC TCC AGC TGG CGC TGT GAT GGT GGC CCC GAC TGC AAG GAC AAA
his ser ser trp arg cys asp gly gly pro asp cys lys asp lys 225
TCT GAC GAG GAA AAC TGC GCT GTG GCC ACC TGT CGC CCT GAC GAA
ser asp glu glu asn cys ala val ala thr cys arg pro asp glu 240
TTC CAG TGC TCT GAT GGA AAC TGC ATC CAT GGC AGC CGG CAG TGT
phe gln cys ser asp gly asn cys ile his gly ser arg gln cys 255
GAC CGG GAA TAT GAC TGC AAG GAC ATG AGC GAT GAA GTT GGC TGC
asp arg glu tyr asp cys lys asp met ser asp glu val gly cys 270
GTT AAT GTG ACA CTC TGC GAG GGA CCC AAC AAG TTC AAG TGT CAC
val asn val thr leu cys glu gly pro asn lys phe lys cys his 285
AGC GGC GAA TGC ATC ACC CTG GAC AAA GTC TGC AAC ATG GCT AGA
ser gly glu cys ile thr leu asp lys val cys asn met ala arg 300
GAC TGC CGG GAC TGG TCA GAT GAA CCC ATC AAA GAG TGC GGG ACC
asp cys arg asp trp ser asp glu pro ile lys glu cys gly thr 315
AAC GAA TGC TTG GAC AAC AAC GGC GGC TGT TCC CAC GTC TGC AAT
asn glu cys leu asp asn asn gly gly cys ser his val cys asn 330
GAC CTT AAG ATC GGC TAC GAG TGC CTG TGC CCC GAC GGC TTC CAG
asp leu lys ile gly tyr glu cys leu cys pro asp gly phe gln 345
CTG GTG GCC CAG CGA AGA TGC GAA GAT ATC GAT GAG TGT CAG GAT
leu val ala gln arg arg cys glu asp ile asp glu cys gln asp 360
CCC GAC ACC TGC AGC CAG CTC TGC GTG AAC CTG GAG GGT GGC TAC
pro asp thr cys ser gln leu cys val asn leu glu gly gly tyr 375
AAG TGC CAG TGT GAG GAA GGC TTC CAG CTG GAC CCC CAC ACG AAG
lys cys gln cys glu glu gly phe gln leu asp pro his thr lys 390
GCC TGC AAG GCT GTG GGC TCC ATC GCC TAC CTC TTC TTC ACC AAC
ala cys lys ala val gly ser ile ala tyr leu phe phe thr asn 405
CGG CAC GAG GTC AGG AAG ATG ACG CTG GAC CGG AGC GAG TAC ACC
arg his glu val arg lys met thr leu asp arg ser glu tyr thr 420
AGC CTC ATC CCC AAC CTG AGG AAC GTG GTC GCT CTG GAC ACG GAG
ser leu ile pro asn leu arg asn val val ala leu asp thr glu 435
GTG GCC AGC AAT AGA ATC TAC TGG TCT GAC CTG TCC CAG AGA ATG
val ala ser asn arg ile tyr trp ser asp leu ser gln arg met 450
ATC TGC AGC ACC CAG CTT GAC AGA GCC CAC GGC GTC TCT TCC TAT
ile cys ser thr gln leu asp arg ala his gly val ser ser tyr 465
GAC ACC GTC ATC AGC AGG GAC ATC CAG GCC CCC GAC GGG CTG GCT
asp thr val ile ser arg asp ile gln ala pro asp gly leu ala 480
GTG GAC TGG ATC CAC AGC AAC ATC TAC TGG ACC GAC TCT GTC CTG
val asp trp ile his ser asn ile tyr trp thr asp ser val leu 495
GGC ACT GTC TCT GTT GCG GAT ACC AAG GGC GTG AAG AGG AAA ACG
gly thr val ser val ala asp thr lys gly val lys arg lys thr 510
TTA TTC AGG GAG AAC GGC TCC AAG CCA AGG GCC ATC GTG GTG GAT
leu phe arg glu asn gly ser lys pro arg ala ile val val asp 525
CCT GTT CAT GGC TTC ATG TAC TGG ACT GAC TGG GGA ACT CCC GCC
pro val his gly phe met tyr trp thr asp trp gly thr pro ala 540
AAG ATC AAG AAA GGG GGC CTG AAT GGT GTG GAC ATC TAC TCG CTG
lys ile lys lys gly gly leu asn gly val asp ile tyr ser leu 555
GTG ACT GAA AAC ATT CAG TGG CCC AAT GGC ATC ACC CTA GAT CTC
val thr glu asn ile gln trp pro asn gly ile thr leu asp leu 570
CTC AGT GGC CGC CTC TAC TGG GTT GAC TCC AAA CTT CAC TCC ATC
leu ser gly arg leu tyr trp val asp ser lys leu his ser ile 585
TCA AGC ATC GAT GTC AAT GGG GGC AAC CGG AAG ACC ATC TTG GAG
ser ser ile asp val asn gly gly asn arg lys thr ile leu glu 600
GAT GAA AAG AGG CTG GCC CAC CCC TTC TCC TTG GCC GTC TTT GAG
asp glu lys arg leu ala his pro phe ser leu ala val phe glu 615
GAC AAA GTA TTT TGG ACA GAT ATC ATC AAC GAA GCC ATT TTC AGT
asp lys val phe trp thr asp ile ile asn glu ala ile phe ser 630
GCC AAC CGC CTC ACA GGT TCC GAT GTC AAC TTG TTG GCT GAA AAC
ala asn arg leu thr gly ser asp val asn leu leu ala glu asn 645
CTA CTG TCC CCA GAG GAT ATG GTC CTC TTC CAC AAC CTC ACC CAG
leu leu ser pro glu asp met val leu phe his asn leu thr gln 660
CCA AGA GGA GTG AAC TGG TGT GAG AGG ACC ACC CTG AGC AAT GGC
pro arg gly val asn trp cys glu arg thr thr leu ser asn gly 675
GGC TGC CAG TAT CTG TGC CTC CCT GCC CCG CAG ATC AAC CCC CAC
gly cys gln tyr leu cys leu pro ala pro gln ile asn pro his 690
TCG CCC AAG TTT ACC TGC GCC TGC CCG GAC GGC ATG CTG CTG GCC
ser pro lys phe thr cys ala cys pro asp gly met leu leu ala 705
AGG GAC ATG AGG AGC TGC CTC ACA GAG GCT GAG GCT GCA GTG GCC
arg asp met arg ser cys leu thr glu ala glu ala ala val ala 720
ACC CAG GAG ACA TCC ACC GTC AGG CTA AAG GTC AGC TCC ACA GCC
thr gln glu thr ser thr val arg leu lys val ser ser thr ala 735
GTA AGG ACA CAG CAC ACA ACC ACC CGG CCT GTT CCC GAC ACC TCC
val arg thr gln his thr thr thr arg pro val pro asp thr ser 750
CGG CTG CCT GGG GCC ACC CCT GGG CTC ACC ACG GTG GAG ATA GTG
arg leu pro gly ala thr pro gly leu thr thr val glu ile val 765
ACA ATG TCT CAC CAA GCT CTG GGC GAC GTT GCT GGC AGA GGA AAT
thr met ser his gln ala leu gly asp val ala gly arg gly asn 780
GAG AAG AAG CCC AGT AGC GTG AGG GCT CTG TCC ATT GTC CTC CCC
glu lys lys pro ser ser val arg ala leu ser ile val leu pro 795
ATC GTG CTC CTC GTC TTC CTT TGC CTG GGG GTC TTC CTT CTA TGG
ile val leu leu val phe leu cys leu gly val phe leu leu trp 810
AAG AAC TGG CGG CTT AAG AAC ATC AAC AGC ATC AAC TTT GAC AAC
lys asn trp arg leu lys asn ile asn ser ile asn phe asp asn 825
CCC GTC TAT CAG AAG ACC ACA GAG GAT GAG GTC CAC ATT TGC CAC
pro val tyr gln lys thr thr glu asp glu val his ile cys his 840
AAC CAG GAC GGC TAC AGC TAC CCC TCG AGA CAG ATG GTC AGT CTG
asn gln asp gly tyr ser tyr pro ser arg gln met val ser leu 855
GAG GAT GAC GTG GCG TGA
glu asp asp val ala ter
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