Рис. LIPC seq.
Нуклеотидная и аминокислотная последовательности
гена печеночной липазы (LIPC) человека
ATG GAC ACA AGT CCC CTG TGT TTC TCC ATT CTG TTG GTT TTA TGC
met asp thr ser pro leu cys phe ser ile leu leu val leu cys 15
ATC TTT ATC CAA TCA AGT GCC CTT GGA CAA AGC CTG AAA CCA GAG
ile phe ile gln ser ser ala leu gly gln ser leu lys pro glu 30
CCA TTT GGA AGA AGA GCT CAA GCT GTT GAA ACA AAC AAA ACG CTG
pro phe gly arg arg ala gln ala val glu thr asn lys thr leu 45
CAT GAG ATG AAG ACC AGA TTC CTG CTC TTT GGA GAA ACC AAT CAG
his glu met lys thr arg phe leu leu phe gly glu thr asn gln 60
GGC TGT CAG ATT CGA ATC AAT CAT CCG GAC ACG TTA CAG GAG TGC
gly cys gln ile arg ile asn his pro asp thr leu gln gln cys 75
GGC TTC AAC TCC TCC CTG CCT CTG GTG ATG ATA ATC CAC GGG TGG
gly phe asn ser ser leu pro leu val met ile ile his gly trp 90
TCG GTG GAC GGC GTG CTA GAA AAC TGG ATC TGG CAG ATG GTG GCC
ser val asp gly val leu glu asn trp ile trp gln met val ala 105
GCG CTG AAG TCT CAG CCG GCC CAG CCA GTG AAC GTG GGG CTG GTG
ala leu lys ser gln pro ala gln pro val asn val gly leu val 120
GAC TGG ATC ACC CTG GCC CAC GAC CAC TAC ACC ATC GCC GTC CGC
asp trp ile thr leu ala his asp his tyr thr ile ala val arg 135
AAC ACC CGC CTT GTG GGC AAG GAG GTC GCG GCT CTT CTC CGG TGG
asn thr arg leu val gly lys glu val ala ala leu leu arg trp 150
CTG GAG GAA TCT GTG CAA CTC TCT CGA AGC CAT GTT CAC CTA ATT
leu glu glu ser val gln leu ser arg ser his val his leu ile 165
GGG TAC AGC CTG GGT GCA CAC GTG TCA GGA TTT GCC GGC AGT TCC
gly tyr ser leu gly ala his val ser gly phe ala gly ser ser 180
ATC GGT GGA ACG CAC AAG ATT GGG AGA ATC ACA GGG CTG GAT GCC
ile gly gly thr his lys ile gly arg ile thr gly leu asp ala 195
GCG GGA CCT TTG TTT GAG GGA AGT GCC CCC AGC AAT CGT CTT TCT
ala gly pro leu phe glu gly ser ala pro ser asn arg leu ser 210
CCA GAT GAT GCC AAT TTT GTG GAT GCC ATT CAT ACC TTT ACG CGG
pro asp asp ala asn phe val asp ala ile his thr phe thr arg 225
GAG CAC ATG GGC CTG AGC GTG GGC ATC AAA CAG CCC ATA GGA CAC
glu his met gly leu arg val gly ile lys gln pro ile gly his 240
TAT GAC TTC TAT CCC AAC GGG GGC TCC TTC CAG CCT GGC TGC CAC
tyr asp phe tyr pro asn gly gly ser phe gln pro gly cys his 255
TCC CTA GAG CTC TAC AGA CAT ATT GCC CAG CAC GGC TTC AAT GCC
ser leu glu leu tyr arg his ile ala gln his gly phe asn ala 270
ATC ACC CAG ACC ATA AAA TGC TCC CAC GAG CGA TCG GTG CAC CTT
ile thr gln thr ile lys cys ser his glu arg ser val his leu 285
TTC ATC GAC TCC TTG CTG CAC GCC GGC ACG CAG AGC ATG GCC TAC
phe ile asp ser leu leu his ala gly thr gln ser met ala tyr 300
CCG TGT GGT GAC ATG AAC AGC TTC AGC CAG GGC CTG TGC CTG AGC
pro cys gly asp met asn ser phe ser gln gly leu cys leu ser 315
TGC AAG AAG GGC CGC TGC AAC ACG CTG GGC TAC CAC GTC CGC CAG
cys lys lys gly arg cys asn thr leu gly tyr his val arg glu 330
GAG CCG CGG AGC AAG AGC AAG AGG CTC TTC CTC GTA ACG CGA GCC
glu pro arg ser lys ser lys arg leu phe leu val thr arg ala 345
CAG TCC CCC TTC AAA GTT TAT CAT TAC CAG TTA AAG ATC CAG TTC
gln ser pro phe lys val tyr his tyr gln leu lys ile gln phe 360
ATC AAC CAA ACT GAG ACG CCA ATA CAA ACA ACT TTT ACC ATG TCA
ile asn gln thr glu thr pro ile gln thr thr phe thr met ser 375
CTA CTC GGA ACA AAA GAG AAA ATG CAG AAA ATT CCC ATC ACT CTG
leu leu gly thr lys glu lys met gln lys ile pro ile thr leu 390
GGC AAA GGA ATT GCT AGT AAT AAA ACG TAT TCC TTT CTT ATC ACG
gly lys gly ile ala ser asn lys thr tyr ser phe leu ile thr 405
CTG GAT GTG GAT ATC GGC GAG CTG ATC ATG ATC AAG TTC AAG TGG
leu asp val asp ile gly glu leu ile met ile lys phe lys trp 420
GAA AAC AGT GCA GTG TGG GCC AAT GTC TGG GAC ACG GTC CAG ACC
glu asn ser ala val trp ala asn val trp asp thr val gln thr 435
ATC ATC CCA TGG AGC ACA GGG CCG CGC CAC TCA GGC CTC GTT CTG
ile ile pro trp ser thr gly pro arg his ser gly leu val leu 450
AAG ACG ATC AGA GTC AAA GCA GGA GAA ACC CAG CAA AGA ATG ACA
lys thr ile arg val lys ala gly glu thr gln gln arg met thr 465
TTT TGT TCA GAA AAC ACA GAT GAC CTA CTA CTT CGC CCA ACC CAG
phe cys ser glu asn thr asp asp leu leu leu arg pro thr gln 480
GAA AAA ATC TTC GTG AAA TGT GAA ATA AAG TCT AAA ACA TCA AAG
glu lys ile phe val lys cys glu ile lys ser lys thr ser lys 495
CGA AAG ATC AGA TGA
arg lys ile arg ter
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