Рис. 16 pat
Нуклеотидная и аминокислотная
последовательности метилмалонил Ко-А
мутазы (MUT) человека.
agtccaaaacaggcctaccagtcagttcttatttctattgggtgtttccatgctccacc atg tta aga gct aag aat cag ctt ttt tta ctt tca cct cat tac met leu arg ala lys asn gln leu phe leu leu ser pro his tyr 15 ctg agg cag gta aaa gaa tca tca ggc tcc agg ctc ata cag caa leu arg gln val lys glu ser ser gly ser arg leu ile gln gln 30 cga ctt cta cac cag caa cag ccc ctt cac cca gaa tgg gct gcc arg leu leu his gln gln gln pro leu his pro glu trp ala ala 45 ctg gct aaa aag cag ctg aaa ggc aaa aac cca gaa gac cta ata leu ala lys lys gln leu lys gly lys asn pro glu asp leu ile 60 tgg cac acc ccg gaa ggg atc tct ata aaa ccc ttg tat tcc aag trp his thr pro glu gly ile ser ile lys pro leu tyr ser lys 75 aga gat act atg gac tta cct gaa gaa ctt cca gga gtg aag cca arg asp thr met asp leu pro glu glu leu pro gly val lys pro 90 ttc aca cgt gga cca tat cct acc atg tat acc ttt agg ccc tgg phe thr arg gly pro tyr pro thr met tyr thr phe arg pro trp 105 acc atc cgc cag tat gct ggt ttt agt act gtg gaa gaa agc aat thr ile arg gln tyr ala gly phe ser thr val glu glu aer asn 120 aag ttc tat aag gac aac att aag gct ggt cag cag gga tta tca lys phe tyr lys asp asn ile lys ala gly gln gln gly leu ser 135 gtt gcc ttt gat ctg gcg aca cat cgt ggc tat gat tca gac aac val ala phe asp leu ala thr his arg gly tyr asp ser asp asn 150 cct cga gtt cgt ggt gat gtt gga atg gct gga gtt gct att gac pro arg leu arg gly asp val gly met ala gly val ala ile asp 165 act gtg gaa gat acc aaa att ctt ttt gat gga att cct tta gaa thr val glu asp thr lys ile leu phe asp gly ile pro leu glu 180 aaa atg tca gtt tcc atg act atg aat gga gca gtt att cca gtt lys met ser val ser met thr met asn gly ala val ile pro val 195 ctt gca aat ttt ata gta act gga gaa gaa caa ggt gta cct aaa leu ala asn phe ile val thr gly glu glu gln gly val pro lys 210 gag aaa ctt act ggt acc atc caa aat gat ata cta aag gaa ttt glu lys leu thr gly thr ile gln asn asp ile leu lys glu phe 225 atg gtt cga aat aca tac att ttt cct cca gaa cca tcc atg aaa met val arg asn thr tyr ile phe pro pro asp pro ser met lys 240 att att gct gac ata ttt gaa tat aca gca aag cac atg cca aaa ile ile ala asp ile phe glu tyr thr ala lys his met pro lys 255 ttt aat tca att tca att agt gga tac cat atg cag gaa gca ggg phe asn ser ile ser ile ser gly tyr his met gln glu ala gly 270 gct gat gcc att ctg gag ctg gcc tat act tta gca gat gga ttg ala asp ala ile leu glu leu ala tyr thr leu ala asp gly leu 285 gag tac tct aga act gga ctc cag gct ggc ctg aca att gat gaa glu tyr ser arg thr gly leu gln ala gly leu thr ile asp glu 300 ttt gca cca agg ttg tct ttc ttc tgg gga att gga atg aat ttc phe ala pro arg leu ser phe phe trp gly ile gly met asn phe 315 tat atg gaa ata gca aag atg aga gct ggt aga aga ctc tgg gct his met glu ile ala lys met arg ala gly arg arg leu trp ala 330 cac tta ata gag aaa atg ttt cag cct aaa aac tca aaa tct ctt his leu ile glu lys met phe gln pro lys asn ser lys ser leu 345 ctt cta aga gca cac tgt cag aca tct gga tgg tca ctt act gag leu leu arg ala his cys gln thr ser gly trp ser leu thr glu 360 cag gat ccc tac aat aat att gtc cgt act gca ata gaa gca atg gln asp pro tyr asn asn ile val arg thr ala ile glu ala met 375 gca gca gta ttt gga ggg act cag tct ttg cac aca aat tct ttt ala ala val phe gly gly thr gln ser leu his thr asn ser phe 390 gat gaa gct ttg ggt ttg cca act gtg aaa agt gct cga att gcc asp glu ala leu gly leu pro thr val lys ser ala arg ile ala 405 agg aac aca caa atc atc att caa gaa gaa tct ggg att ccc aaa arg asn thr gln ile ile ile gln glu glu ser gly ile pro lys 420 gtg gct gat cct tgg gga ggt tct tac atg atg gaa tgt ctc aca val ala asp pro trp gly gly ser tyr met met glu cys leu thr 435 aag ctc att aat gaa att gaa gaa atg ggt gga atg gcc aaa gct lys leu ile asn glu ile glu glu met gly gly met ala lys ala 450 gta gct gag gga ata cct aaa ctt cga att gaa gaa tgt gct gcc val ala glu gly ile pro lys leu arg ile glu glu cys ala ala 465 cga aga caa gct aga ata gat tct ggt tct gaa gta att gtt gga arg arg gln ala arg ile asp ser gly ser glu val ile val gly 480 gta aat aag tac cag ttg gaa aaa gaa gac gct gta gaa gtt ctg val asn lys tyr gln leu glu lys glu asp ala val glu val leu 495 gca att gat aat act tca gtg cga aac agg cag att gaa aaa ctt ala thr asp asn thr ser val arg asn arg gln ile gly lys leu 510 aag aag atc aaa tcc agc agg gat caa gct ttg gct gaa cat tgt lys lys ile lys ser ser arg asp gln ala leu ala glu his cys 525 ctt gct gca cta acc gaa tgt gct gct agc gga gat gga aat atc leu ala ala leu thr glu cys ala ala ser gly asp gly asn ile 540 ctg gct ctt gca gtg gat gca tct cgg gca aga tgt aca gtg gga leu ala leu ala val asp ala ser arg ala arg cys thr val gly 555 gaa atc aca gat gcc ctg aaa aag gta ttt ggt gaa cat aaa gcg glu ile thr asp ala leu lys lys val phe gly glu his lys ala 570 aat gat cga atg gtg agt gga gca tat cgc cag gaa ttt gga gaa asn asp arg met val ser gly ala tyr arg gln glu tyr gly glu 585 agt aaa gag ata aca tct gct atc aag agg gtt cat aaa ttc atg ser lys glu ile thr ser ala ile lys arg val his lys phe met 600 gaa cgt gaa ggt cgc aga cct cgt ctt ctt gta gca aaa atg gga glu arg glu gly arg arg pro arg leu leu val ala lys met gly 615 caa gat ggc cat gac aga gga gca aaa gtt att gct aca gga ttt gln asp gly his asp arg gly ala lys val ile ala thr gly phe 630 gct gat ctt ggt ttt gat gtg gac ata ggc cct ctt ttc cag act ala asp leu gly phe asp val asp ile gly pro leu phe gln thr 645 cct cgt gaa gtg gcc cag cag gct gtg gat gcg gat gtg cat gct pro arg glu val ala gln gln ala val asp ala asp val his ala 660 gtg ggc gta agc acc ctc gct gct ggt cat aaa acc cta gtt cct val gly val ser thr leu ala ala gly his lys thr leu val pro 675 gaa ctc atc aaa gaa ctt aac tcc ctt gga cgg cca gat att ctt glu leu ile lys glu leu asn ser leu gly arg pro asp ile leu 690 gtc atg tgt gga ggg gtg ata cca cct cag gat tat gaa ttt ctg val met cys gly gly val ile pro pro gln asp tyr glu phe leu 705 ttt gaa gtt ggt gtt tcc aat gta ttt ggt cct ggg act cga att phe glu val gly val ser asn val phe gly pro gly thr arg ile 720 cca aag gct gcc gtt cag gtg ctt gat gat att gag aag tgt ttg pro lys ala ala val gln val leu asp asp ile glu lys cys leu 735 gaa aag aag cag caa tct gta taa tatcctctttttgttttagcttttgtct glu lys lys gln gln ser val aaaatattattttagttatgatcaaagaagagagtaaagctatgtcttcaatttaatttc aatacctgatttgtactttccttgaaagctttactttaaaataccttacttataggcctg gtgtcatgctataagtatgtacatacagtttcacttcaaaaataaaaaaaaatccctaaa aactctctatactctctataacaatactttatcaagaactctggacaatggtattatttt taaaaatcatggtgatgtatttattagaatgtttcttataaatctctttcatttttatat taagaattaaactgtacctaaaaaaactctgactattcccatttctcagtttagcattac attgtcttgagcaccagaaaataaaatccatatattaattaaaacctatcttgaaaaaaa aaaaaaaaaaaaaaaaaaaaaСсылки:
