Биология и медицина

Рис. 15 pat

              Нуклеотидная (кДНК) и аминокислотная
               последовательности фумарилацетоацетат
                     ацетазы (FAA) человека

                                        cctcctagccaagaccgag
gataggtgtggccattggcgaccagatcctggacctcagcatcatcaagcacctcttta
ctggtcctgtcctctccaaacaccaggatgtcttcaatcagcctacactcaacagcttc

atg ggc ctg ggt cag gct gcc tgg aag gag gcg aga gtg ttc ttg
met gly leu gly gln ala ala trp lys glu ala arg val phe leu	15

cag aac ttg ctg tct gtg agc caa gcc agg ctc aga gat gac acc
gln asn leu leu ser val ser gln ala arg leu arg asp asp thr	30

gaa ctt cgg aag tgt gca ttc atc tcc cag gct tct gcc acg atg
glu leu arg lys cys ala phe ile ser gln ala ser ala thr met	45

cac ctt cca gcc acc ata gga gac tac aca gac ttc tat tcc tct
his leu pro ala thr ile gln asp tyr thr asp phe tyr ser ser	60

cgg cag cat gct acc aac gtc gga atc atg ttc agg gac aag gag
arg gln his ala thr asn val gln ile met phe arg asp lys glu	75

aat gcg ttg atg cca aat tgg ctg cac tta cca gtg ggc tac cat
asn ala leu met pro asn trp leu his leu pro val gln tyr his	90

ggc cgt gcc tcc tct gtc gtg gtg tct ggc acc cca atc cga agg
gln arg ala ser ser val val val ser gln thr pro ile arg arg	105

ccc atg gga cag atg aaa cct gat gac tct aag cct ccc gta tat
pro met gly gln met lys pro asp asp ser lys pro pro val tyr	120

ggt gcc tgc aag ctc ttg gac atg gag ctg gaa atg gct ttt ttt
gly ala cys lys leu leu asp met glu leu glu met ala phe phe	135

gta ggc cct gga aac aga ttg gga gag ccg atc ccc att tcc aag
val gly pro gly asn arg leu gly glu pro ile pro ile ser lys	150

gcc cat gag cac att ttt gga atg gtc ctt atg aac gac tgg agt
ala his glu his ile phe gly met val leu met asn asp trp ser	165

gca cga gac att cag aag tgg gag tat gtc cct ctc ggg cca ttc
ala arg asp ile gln lys trp glu tyr val pro leu gly pro phe	180

ctt ggg aag agt ttt ggg acc act gtc tct ccg tgg gtg gtg ccc
leu gly lys ser phe gly thr thr val ser pro trp val val pro	195

atg gat gct ctc atg ccc ttt gct gtg ccc aac ccg aag cag gac
met asp ala leu met pro phe ala val pro asn pro lys gln asp	210

ccc agg ccc ctg ccg tat ctg tgc cat gac gag ccc tac aca ttt
pro arg pro leu pro tyr leu cys his asp glu pro tyr thr phe	225

gac atc aac ctc tct gtt aac ctg aaa gga gaa gga atg agc cag
asp ile asn leu ser val asn leu lys gly glu gly met ser gln	240

gcg gct acc ata tgc aag tcc aat ttt aag tac atg tac tgg acg
ala ala thr ile cys lys ser asn phe lys tyr met tyr trp thr	255

atg ctg cag cag ctc act cac cac tct gtc aac ggc tgc aac ctg
met leu gln gln leu thr his his ser val asn gly cys asn leu	270

cgg ccg ggg gac ctc ctg gct tct ggg acc atc agc ggg ccg gag
arg pro gly asp leu leu ala ser gly thr ile ser gly pro glu	285

cca gaa aac ttc ggc tcc atg ttg gaa ctg tcg tgg aag gga acg
pro glu asn phe gly ser met leu glu leu ser trp lys gly thr	300

aag ccc ata gac ctg ggg aat ggt cag acc agg aag ttt ctg ctg
lys pro ile asp leu gly asn gly gln thr arg lys phe leu leu	315

gac ggg gat gaa gtc atc ata aca ggg tac tgc cag ggg gat ggt
asp gly asp glu val ile ile thr gly tyr cys gln gly asp gly	330

tac cgc atc ggc ttt ggc cag tgt gct gga aaa gtg ctg cct gct
tyr arg ile gly phe gly gln cys ala gly lys val leu pro ala	345

ctc ctg cca tca tga gattttctctgctcttctggaaacaaagggctcaagcac
leu leu pro ser ter

ccctttcaaccctgtgactggggtcctccctcgggctgtaggcctggtccgctattcag
tgacaaataaagccattgtgctctgaaaaaaaaaaa


		

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Тирозинемия I типа: генетика