Gene: [01p13/CD2] antigen CD2 (p50; mono-antibodies Leu5, T11, 9.6, 35.1); sheep red blood cell receptor; antigen CD58 receptor (rosette receptor); [GP50 SRBC ]
GEN | The gene length is 12 kb; exons: 5. |
MOP | The product is a
transmembrane glycoprotein with the MM 50 kD; the MM of apoprotein is 38 kD
(about 330 amino acid residues); it consists of three domains, the
extracellular, membrane, and cytoplasmic ones (180, 40, and 110 amino acid residues, respectively)." |
EVO | The peptide has confined regions that are homologues to the amino acid sequences of immunoglobulins." |
REL | GEM:01p13/CD58. |
FUN | The CD2 antigen is supposed to participate in T cell activation. |
REF | LOC "Brown MH &: Hum Genet, 76, 191-195, 1987 LOC,CAG "Clayton &: J Immunol, 140, 3617-3621, 1988 CAG,GEN,SEQ "Diamond DJ &: PNAS, 85, N5, 1615-1619, 1988 GEN,STR,EXP,ENG "Lang G &: EMBO J, 7, N6, 1675-1682, 1988 FUN,MEB "Parish &: J Immunol, 141, N10, 3498-3504, 1988 PRO,SEQ,MOP,FAG "Sayre PH &: PNAS, 84, N9, 2941-2945, 1987 PRO,SEQ,MOP,FAG "Seed B, Aruffo: PNAS, 84, N10, 3365-3369, 1987 PRO,SEQ,MOP,FAG "Sewell WA &: PNAS, 83, N22, 8718-8722, 1986 |
SWI | SWISSPROT: P06729 |
KEY | imm, img, recp, mem |
CLA | coding, basic |
LOC | 01 p13 |
MIM | MIM: 186990 |
SYN | GP50 SRBC |
