Gene: [01p36/BCS2] breast-ovarian cancer, familial; [BRCD2 BCDS2 ]

COM

The locus have been mapped on the basis of the close linkage with Rhesus antigen in families with uni- or bilateral breast cancer and/or with primarilly multiple (uni- or bilateral) ovarian cancer. In some cases, the relatives with cystic fibrous degeneration of mammary glands (but not fibradenoma) were also included in the counting of the general prevalence (i.e., in the number of affected with incomplete gene expression) to increase the informativeness."

FAG

Since several genes that are directly or indirectly involved in carcinogenesis are mapped in this region of chr 1p3 (GEM:01p36/A12M2, GEM:01p36/CMM, GEM:01p3/ERVPL1, GEM:01p36/FGR, GEM:01p32/BLYM, GEM:01p32/MYCL1, GEM:01p3/JUN, GEM:01p3/LCK, GEM:01p36/NBL1, and GEM:01p3/RAB3B), the hypothesis of independence of the BCS2 locus requires additional verification."

HET

About other forms of breast cancer, see GEM:01q2/SKI, GEM:11p155/ADCR, GEM:13^/BCS1, GEM:17q21/BRCA1, GEM:21q223/TFF1."

REF

LOC,LIN "Anderson &: CCG, 40, (HGM8), 568-569, 1985
LOC,LIN "Ferrell RE &: Cancer Genet Cytogenet, 38, 241-248, 1989
PAT,PHE,FOG "Fraumeni &: Cancer, 36, 364-369, 1975
PAT,PHE,FOG "Lynch &: Cancer, 41, 1543-1549, 1978

KEY

onc, horm, sex

CLA

unknown, basic

LOC

01 p36

MIM

MIM: 211420

SYN

BRCD2 BCDS2