Gene: [01p3/LCK] lymphocyte-specific protein tyrosine kinase (protooncogene LCK); protooncogene LCK (protein tyrosine kinase, lymphocyte-specific);

COM

 [1] Insertion of the murine leukemia virus (Moloney) into the 5'-proximity of the murine LCK gene (on Chr 4) results in its rearrangement and overexpression in Lstra lymphoma (Marth-1986). The corresponding human homologue is located to a chromosome segment whose rearrangements are often found in lymphomas and neuroblastomas.
[2] Other names: tyrosylprotein kinase; hydroxyarylaryl-protein kinase."

FUN

 [1] Systematic name: ATP:protein-tyrosine O-phosphotransferase.
[2] Reaction catalyzed: ATP + protein tyrosine = ADP + protein tyrosine phosphate."

REF

 FUN,MCH "Anderson SJ &: Nature, 365, 552-554, 1993
PAT,CHR,ABR "Burnett RC &: Genes Chromosom Cancer, 3, 461-467, 1991
FUN,PEP,FAG "Hunter T, Sefton BM: PNAS, 77, N3, 1311-1315, 1980
TRL,EXP,FUN,MEB "Marth JD &: Nature, 332, 171-173, 1988
COM,LOC,CYG "Marth JD &: PNAS, 83, N19, 7400-7404, 1986
PAT,CHR,ABR "Tycko B &: J Exp Med, 174, 867-873, 1991
LOC,MAP "Van Roy N &: Genomics, 18, N1, 71-78, 1993
FUN,PEP "Van Tan H &: Eur J Biochem, 172, N1, 67-72, 1988
LOC,CYG,MOL "Volpi EV &: CCG, 67, 187-189, 1994

KEY

 imm, onc, pep

CLA

 coding, basic

LOC

 01 p35-34.3

MIM

 MIM: 153390

EZN

 ENZYME: 2.7.1.112?

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