Gene: [01q32/TNNI1] troponin I1, skeletal, slow; [TNN1 ]
COM | Corin-1994 have cloned the gene encoding the human slow twitch skeletal muscle isoform of troponin I and have identified 5'-flanking sequences required for its expression in skeletal muscle cells (Corin-1994)." |
GEN | The gene length: 12.5 kb; exons: 9 (Corin-1994). |
EXP | The 'slow' isoform of troponin I is expressed during early heart and skeletal muscle development but is restricted to slow twitch skeletal muscle in the adult. In contrast to many muscle-specific genes, the troponin I promoter does not contain consensus CCAAT or TATA elements. Moreover, the sequence from -9 to +11 resembles an 'initiator element' previously shown to direct transcription of some tissue-specific genes lacking TATA boxes (Calvo-1996). A transcriptional fusion construct, comprising 4.2 kilobases of troponin I 5'-flanking DNA linked to the bacterial chloramphenicol acetyl-transferase gene, exhibited cell type-specific and developmentally regulated expression. A muscle-specific enhancer regulated slow troponin I promoter activity (Corin-1994)." |
REF | TRC,GEN "Calvo &: Dev
Genet, 19, N2, 169-181, 1996 GEN,SEQ,EXP "Corin SJ &: JBC, 269, 10651-10659, 1994 LOC "Eyre HJ &: CCG, 62, N2-3, 181-182, 1993 COD,SEQ,LOC,EXP "Wade R &: Genomics, 7, 346-357, 1990 GEN,EXP,EVO "Weis L, Reinberg D: FASEB J, 6, 3300-3309, 1992 |
SWI | SWISSPROT: P19237 |
KEY | myo |
CLA | coding, basic |
LOC | 01 q32 |
MIM | MIM: 191042 |
SYN | TNN1 |
