Gene: [02p13/TGFA] transforming growth factor, alpha; [TGF1 ETGF ]

FAG

Two transforming factor types are known that was isolated from various tumor cells and can reversibly transform cultured normal mammalian cells. They are referred to as alpha and beta peptides. The alpha peptides (truncated derivatives of a common precursor) share homology with epidermal growth factor (GEM:04q25/EGF) and possess affinity to its receptor (GEM:07p12/EGFR1), while the beta peptides (GEM:19q131/TGFB1) do not belong to this gene family."

REF

FUN,MOP,EXP,ENG "Brachmann &: Cell, 56, (Feb 24), 691-700, 1989
LOC,MOL "Brissenden JE &: CCG, 40, (HGM8), 589, 1985a
LOC,MOL "Brissenden JE &: Cancer Res, 45, 5593-5597, 1985b
FUN,CLO,SEQ "Derynck R &: Cell, 38, (Aug), 287-297, 1984
FUN,PAT "Ellis &: New Engl J Med, 317, 1582-1587, 1987
LOC,MOL "Francke &: Cold Spring Harbor Symp, 51, 855-866, 1986
FUN,MOP,EXP,ENG "Tam &: PNAS, 83, N21, 8082-8086, 1986
LOC,MOL "Tricoli JV &: CCG, 42, 94-98, 1986
LOC,MOL "Tricoli JV &: CCG, 40, (HGM8), 762, 1985

SWI

 SWISSPROT: P01135

KEY

onc

CLA

coding, basic

LOC

02 p13

MIM

 MIM: 190170

SYN

TGF1 ETGF

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