Gene: [19p133/AMH] anti-Mullerian hormone (mullerian inhibiting factor); persistent Mullerian duct syndrome, type I (pseudohermaphroditism, male internal; MIM:261550);

GEN

The gene length is no more than 3 kb. Exons: 5.

PRO

Cohen-Haguenauer-1987 mentioned AMH probe, which was used for localization of this gene, however they did not describe its characteristics."

MOP

The peptide product of AMH gene has MM 65 kD (mRNA is 2.1 kb); posttranslational glycosilation increases its MM to 72 kD. The mature anti-Mullerian hormone is a homodimer. It is produced by testicle Sertoli's cells, mainly at prenatal period and to a less extent, during postnatal life and in adults."

FAG

[1] Anti-Mullerian hormone receptor is mapped to Chr 12q13 (GEM:12q13/AMHR2).
[2] One of AMH-related markers, beta 1 transforming growth factor gene, is mapped to Chr 19q131 (GEM:19q131/TGFB1)."

REL

GEM:19p133/AMH; GEM:02q3/INHA; GEM:07p1/INHBA; GEM:02q1/INHBB; GEM:19q131/TGFB1; GEM:01q41/TGFB2; GEM:14q24/TGFB3; GEM:02p13/TGFA"

REF

MUT "Carre-Eusebe D &: Hum Genet, 90, 389-394, 1992
PRO,GEN,SEQ,MOP,EVO,EXP "Cate RL &: Cell, 45, 685-698, 1986
PRO,LOC,MOL "Cohen-Haguenauer &: CCG, 44, N1, 2-6, 1987
PRO,GEN,SEQ,MOP,EVO,EXP "Guerrier &: J Reprod Fert, 88, N2, 695-706, 1990
GEN,MOL,PAT "Imbeaud S &: Hum Mol Genet, 3, 125-131, 1994
REV,MEB,FUN "Josso, Picard: Physiol Rev, 66, 1038-1090, 1986
MUT "Knebelmann B &: PNAS, 88, 3767-3771, 1991
PRO,MAM,EXP,MOP "Picard &: PNAS, 83, N15, 5464-5468, 1986
MEB,FUN "Picard, Josso: Mol Cell Endocrinol, 34, 23-29, 1984

KEY

sex, horm, ont

CLA

coding, basic

LOC

19 p13.3

MIM

MIM: 600957

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