Gene: [19p133/AMH] anti-Mullerian hormone (mullerian inhibiting factor); persistent Mullerian duct syndrome, type I (pseudohermaphroditism, male internal; MIM:261550);
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GEN |
The gene length is no more than 3 kb. Exons: 5. |
|
PRO |
Cohen-Haguenauer-1987 mentioned AMH probe, which was used for localization of this gene, however they did not describe its characteristics." |
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MOP |
The peptide product of AMH gene has MM 65 kD (mRNA is 2.1 kb); posttranslational glycosilation increases its MM to 72 kD. The mature anti-Mullerian hormone is a homodimer. It is produced by testicle Sertoli's cells, mainly at prenatal period and to a less extent, during postnatal life and in adults." |
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FAG |
[1] Anti-Mullerian hormone receptor is mapped to Chr 12q13 (GEM:12q13/AMHR2).
[2] One of AMH-related markers, beta 1 transforming growth factor gene, is mapped to Chr 19q131 (GEM:19q131/TGFB1)." |
|
REL |
GEM:19p133/AMH; GEM:02q3/INHA; GEM:07p1/INHBA; GEM:02q1/INHBB; GEM:19q131/TGFB1; GEM:01q41/TGFB2; GEM:14q24/TGFB3; GEM:02p13/TGFA" |
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REF |
MUT "Carre-Eusebe D &: Hum Genet, 90, 389-394, 1992 PRO,GEN,SEQ,MOP,EVO,EXP "Cate RL &: Cell, 45, 685-698, 1986 PRO,LOC,MOL "Cohen-Haguenauer &: CCG, 44, N1, 2-6, 1987 PRO,GEN,SEQ,MOP,EVO,EXP "Guerrier &: J Reprod Fert, 88, N2, 695-706, 1990 GEN,MOL,PAT "Imbeaud S &: Hum Mol Genet, 3, 125-131, 1994 REV,MEB,FUN "Josso, Picard: Physiol Rev, 66, 1038-1090, 1986 MUT "Knebelmann B &: PNAS, 88, 3767-3771, 1991 PRO,MAM,EXP,MOP "Picard &: PNAS, 83, N15, 5464-5468, 1986 MEB,FUN "Picard, Josso: Mol Cell Endocrinol, 34, 23-29, 1984 |
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KEY |
sex, horm, ont |
|
CLA |
coding, basic |
|
LOC |
19 p13.3 |
|
MIM |
MIM: 600957 |
