Gene: [07p1/INHBA] inhibin, beta A; activin, beta A; follicle-stimulating hormone (FSH)-releasing protein; erythroid differentiation factor; [EDF ]

FUN

Beta-A inhibin gene encodes one of the chains of inhibins and activins - gonadal glycoprotein hormones - that regulate the secretion of the hypophyseal follicle stimulating hormone (FSH). Beta polypeptide of FSH - follitropin beta - is mapped to Chr 11 (GEM:11p13/FSHB). For more details, see FAM:INH/00.0."

FAG

[1] Beta-B inhibin gene is assigned to Chr 2 (GEM:02q1/INHBB). Beta-C inhibin gene is mapped to Chr 12 (GEM:12q131/INHBC).
[2] See also FAM:INH/00.0."

MOP

[1] Inhibin beta peptides have MM 10.7 kD (94 amino acids) and have been shown to be unglycosilated. In SDS electrophoresis, the beta peptide is revealed at the 14-kD band, however this is thought to be a result of abnormal migration in such a gele.
[2] On the alpha peptide structure, see GEM:07p1/INHBA.
[3] Structure of inhibin as a whole is described in FAM:INH/00.0."

REF

LOC,FAG,EVO "Barton &: CCG, 46, (HGM9), 578, 1987
MOP,SEQ "Mason AJ &: BBRC, 135, 957-964, 1986
SEQ "Mason AJ &: Nature, 318, 659-663, 1985

SWI

SWISSPROT: P08476

KEY

sex, horm

CLA

coding, basic

LOC

07 p15-13

MIM

MIM: 147290

SYN

EDF

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