Gene: [19q131/TGFB1] transforming growth factor, beta 1; [TGFB ]

FUN

 Transforming growth factors (TGFs) have both stimulatory and inhibitory effects on growth of different cell types and play a role in the production and degradation of the extracellular matrix. TGF-beta molecules are secreted in the form of latent large molecular weight complexes that contain other proteins, such as latent TGF-beta-1 binding proteins (see on them in 02/LTBP1)."

FAG

 [1] The following human transforming growth factor-beta genes are currently mapped: GEM:19q131/TGFB1; GEM:01q41/TGFB2; GEM:14q24/TGFB3; GEM:01q421/TGFB4. Despite the functional similarity with alpha transforming growth factor (GEM:02p13/TGFA), beta transforming growth factor belongs to another multigene family (along with inhibins and activins, FAM:INH/00.0).
[2] About latent TGFB binding proteins see GEM:02^/LTBP1.
[3] On TGFB1 response element see GEM:18q2/TGFBRE.
[4] On TGFB1 induced transcript 1 see GEM:00.0/TGFB1I1."

MOP

 The native beta transforming growth factor is a homodimer; the subunits comprise 112 amino acids each."

REF

 POL,MOL "Ardinger &: NAR, 16, 8202, 1988
COM,FAG,EVO "Barton DE &: Oncogene Res, 3, 323-331, 1988
FUN,EXP,MEB "Boyd, Massague: JBC, 264, N4, 2272-2278, 1989
LOC,LIN,MAP "Brook &: CCG, 46, (HGM9), 587, 1987
CLO,SEQ,EXP "Derynck R &: Nature, 316, 701-705, 1985
FUN,EXP,MEB "Edwards &: EMBO J, 6, N7, 1899-1904, 1987
CLO,LOC,MOL "Fujii D &: Somat Cell Mol Genet, 12, 281-288, 1986
CLO,LOC,MOL "Fujii D &: CCG, 40, (HGM8), 632, 1985
REV,FUN,EXP,MEB "Hsuan &: Brit Med Bull, 45, N2, 425-437, 1989
LOC,LIN,MAP "Hulsebos T &: CCG, 43, 47-56, 1986
FUN,MEB "Ignotz &: JBC, 264, N1, 389-392, 1989
FUN "Khanna A &: BBRC, 204, 1061-1066, 1994
GEN,SEQ,TRC "Kim &: JBC, 264, N1, 402-408, 1989a
GEN,SEQ,TRC "Kim &: JBC, 264, N12, 7041-7045, 1989b
PEP,SEQ "Marquardt H &: JBC, 262, N25, 12127-12131, 1987
REV,FUN,EXP,MEB "Massague J: Cell, 49, 437-438, 1987
FUN,EXP,MEB "Roberts &: PNAS, 83, N12, 4167-4171, 1986
LIN,MAF "Schonk D &: CCG, 51, (HGM10), 1075, 1989a
LIN,MAF "Schonk D &: Genomics, 4, N3, 384-396, 1989b
REV,FUN,EXP,MEB "Sporn &: J Cell Biol, 105, 1039-1045, 1987
FUN,EXP,MEB "Sporn &: Science, 233, 532-534, 1986

KEY

 exce, cyk

CLA

 coding, basic

LOC

 19 q13.1

MIM

 MIM: 190180

SYN

 TGFB

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