Gene: [08q243/GPT] glutamic-pyruvate transaminase; alanine aminotransferase 1, soluble;
POL | The two polymorphic GPT isozymes are the results of a nucleotide substitution in codon 14, coding for a histidine in GPT-1 (erythrocyte form) and an asparagine in GPT-2 (hepatic form), which causes a gain or loss of an NlaIII restriction site (Sohocki-1997)." |
FUN | Systematic name: L-alanine:2-oxoglutarate aminotransferase. The reaction catalyzed: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate." |
REF | PEP,SEQ
"Doyle JM &: Biochem J, 270, N3, 651-657, 1990 LOC,CYG "Jeremiah &: CCG, 37, (HGM7), 498, 1984 LIN,MAG "O'Connell &: CCG, 46, (HGM9), 673, 1987 LOC,CYG "Rocha J &: Hum Genet, 80, 299-300, 1988 CLO,SEQ,LOC,POL "Sohocki MM &: Genomics, 40, N2, 247-252, 1997 |
SWI | SWISSPROT: P24298 |
KEY | hem, ant, aac |
CLA | coding, basic |
LOC | 08 q24.3 |
MIM | MIM: 138200 |
EZN | ENZYME: 2.6.1.2 |
