Gene: [09p21/CDKN2A] cyclin-dependent kinase inhibitor 2A (melanoma, p16); multiple tumor suppressor 1; melanoma, cutaneous malignant 2 (without dysplastic nevus syndrome) (MIM:155601); [MTS1 CMM2 ]

FUN

CDKN2A inhibits cyclin-dependent kinase CDK4 (see GEM:12q13/CDK4).

REF

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FUN "Bergman W &: J Invest Derm, 103, 122S-125S, 1994
MUT "Cairns P &: Nature Genet, 11, 210-212, 1995
MUT "Cairns P &: Science, 265, 415-416, 1994
MUT "Caldas C &: Nature Genet, 8, 27-32, 1994
FUN "Cannon-Albright LA &: Genomics, 23, 265-268, 1994
PAT "Ciotti P &: New Engl J Med, 334, 469-470, 1996
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LOC,MUT "Fountain JW &: PNAS, 89, 10557-10561, 1992
MUT "Goldstein AM &: New Engl J Med, 333, 970-974, 1995
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MUT "Gruis NA &: Nature Genet, 10, 351-353, 1995b
MUT "Hayashi N &: BBRC, 202, 1426-1430, 1994
MUT "Hebert J &: Blood, 84, 4038-4044, 1994
POL "Herbst RA &: Hum Mol Genet, 3, N12, 2265, 1994
MUT "Hussussian CJ &: Nature Genet, 8, 15-21, 1994
MUT "Igaki H &: BBRC, 203, 1090-1095, 1994
FUN "Isshiki K &: Oncogene, 9, 1649-1653, 1994
FUN "Jen J &: Cancer Res, 54, 6353-6358, 1994
MUT "Kamb A &: Nature Genet, 8, 23-26, 1994a
CLO,SEQ "Kamb A &: Science, 264, 436-440, 1994b
MUT "Koh J &: Nature, 375, 506-510, 1995
MUT "Liu L &: Oncogene, 11, 405-412, 1995a
MUT "Liu Q &: Oncogene, 10, 619-622, 1995b
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FUN "Lukas J &: Nature, 375, 503-506, 1995
FUN "MacGeoch C &: Hum Mol Genet, 3, 2195-2200, 1994
FUN "Merlo A &: Nature Med, 1, 686-692, 1995
MUT "Mori T &: Cancer Res, 54, 3396-3397, 1994
MUT "Nobori T &: Nature, 368, 753-756, 1994
MUT "Ogawa S &: Blood, 84, 2431-2435, 1994
MUT "Okamoto A &: PNAS, 91, 11045-11049, 1994
MUT "Okuda T &: Blood, 85, 2321-2330, 1995
MUT "Petty EM &: Am J Med Genet, 45, 77-80, 1993
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FUN "Porterfield BW &: Somat Cell Mol Genet, 20, 391-400, 1994
MUT "Puig S &: AJHG, 57, 395-402, 1995
CLO,SEQ,STR,PEP "Quelle DE &: Cell, 83, 993-1000, 1995
MUT "Ranade K &: Nature Genet, 10, 114-116, 1995
FUN "Serrano M &: Cell, 85, 27-37, 1996
CLO,SEQ "Serrano M &: Nature, 366, 704-707, 1993
MUT "Smith-Sorensen B, Hovig E: Hum Mut, 7, 294-303, 1996
CLO,SEQ,GEN,FUN "Stone S &: Cancer Res, 55, 2988-2994, 1995
PAT "Wainwright B &: Nature Genet, 8, 3-5, 1994
MUT "Walker GJ &: Hum Mol Genet, 4, 1845-1852, 1995
FUN "Walker GJ &: Oncogene, 9, 819-824, 1994
MUT "Whelan AJ &: New Engl J Med, 333, 975-977, 1995
MUT "Williamson MP &: Hum Mol Genet, 4, 1569-1577, 1995

SWI

 SWISSPROT: P42771

KEY

nucm, onc, repr, derm, pigm

CLA

coding, basic

LOC

09 p21

MIM

 MIM: 600160

SYN

MTS1 CMM2

Ссылки: