Gene: [10p112/ITGB1] integrin, beta 1 (antigen CD29 includes MDF2, MSK12); fibronectin receptor, beta polypeptide (antigen CD29 includes MDF2, MSK12); very late activation protein-4 receptor, beta-4 subunit (antigen CD29); [FNRB CD29 ]
FAG | [1] An
ITGB1/FNRB-like sequence was found in chr 19p (GEM:19p1/ITGB1L). [2] On the group of genes that are functionally related to fibronectin, see GEM:02q34/FN1." |
PRO | Probe pGEM-32 contains a 2.485-kb cDNA fragment cloned at EcoRI site in the plasmid pGEM1. The probe identifies two fragments, 11.4 and 23 kb in length, in the EcoRI hydrolizate of human gDNA (and only one fragment, 9.1 kb, in the murine gDNA)." |
HIS | According to Goodfellow-1989, the antigens MDF2 (monoclonal antibodies A-1A5) and MSK12 (monoclonal antibodies AJ2/AJS), which genes were mapped in chr 10 and registered previously as indipendent markers, are actually identical to beta subunit of the fibronectin receptor. Therefore MDF2 and MSK12 was excluded from the catalogue." |
REF | CLO,SEQ,EXP "Argraves WS &: J Cell Biol, 105, 1183-1190,
1987 LOC,MOL,MAP "Carson, Simpson: CCG, 51, (HGM10), 974-975, 1989 LOC,MOL,PRO "Goodfellow &: Ann Hum Genet, 53, 15-22, 1989 LIN,MAG "Myers &: CCG, 51, (HGM10), 1050, 1989 LOC,CYG "Peters PM &: J Exp Med, 159, 1441-1454, 1984 LOC,CYG "Rettig WJ &: PNAS, 81, 6437-6441, 1984 LIN,MAG "Wu &: CCG, 51, (HGM10), 1110-1111, 1989 LOC,CYG "Zhang &: Somat Cell Mol Genet, 14, 99-104, 1988 |
SWI | SWISSPROT: P05556 |
KEY | mem, recp |
CLA | coding, basic |
LOC | 10 p11.2 |
MIM | MIM: 135630 |
SYN | FNRB CD29 |
