Gene: [12q1/ITGA5] integrin, alpha 5 (alpha F; antigen CD49E); fibronectin receptor, alpha polypeptide; [VLA5A CD49E ]

FAG

[1] The gene for the beta subunit of fibronectin receptor is mapped in the short arm of chr 10 (GEM:10p112/ITGB1); in chr 19p, a FNRB-like sequence was found (GEM:19p1/ITGB1L).
[2] On the gene group that is functionally related with fibronectin, see GEM:02q34/FN1."

EVO

Homology was revealed between alpha peptides of platelet glycoprotein IIB (GEM:17q2132/ITGB3), fibronectin receptor (GEM:12q1/ITGA5), and vitronectin receptor (GEM:02q3/ITGAV); all the three genes belong to the integrin family."

REL

FAM:ITG/00.0

REF

PRO,SEQ,EXP "Argraves WS &: J Cell Biol, 105, 1183-1190, 1987
PRO,SEQ,EXP "Argraves WS &: JBC, 261, 12922-12924, 1986
LOC,MOL,PRO "Sosnoski DM &: J Clin Invest, 81, 1993-1998, 1988

SWI

 SWISSPROT: P08648

KEY

mem, recp

CLA

coding, basic

LOC

12 q11-13

MIM

 MIM: 135620

SYN

VLA5A CD49E

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