Gene superfamily: integrins; (ITGA1 ITGA2 ITGA2B ITGA3 ITGA4 ITGA4L ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAW ITGAX ITGB1 ITGB1L ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8)

SUM

Integrins are a large family of cell surface alpha-beta heterodimers involved in cell-cell and cell-extracellular matrix interactions."

EVO

A homology was found between platelet glycoprotein IIB alpha peptides (GEM:17q2132/ITGB3), fibronectin receptor (GEM:12q1/ITGA5), and vitronectin receptor (GEM:02q3/ITGAV). All the three genes belong to the integrin superfamily."

REF

REV,FUN,MEB,EVO "Hynes RO: Cell, 48, 549-554, 1987