Gene: [10p1/IL15RA] interleukin 15 receptor, alpha;
|
SUM |
[1] The receptor for interleukin 15 consists of one specific subunit -
alpha, which is required for high affinity IL15 binding, and two
non-specific subunits (GEM:22q13/IL2RB;
GEM:0Xq131/IL2RG), which are
essential for signal transduction and may bind (with low affinity) not
only IL15 (GEM:04q31/IL15) but IL2 (GEM:04q2/IL2) as well.
[2] The cytoplasmic domain of IL15R-alpha, like that of IL2R-alpha, is dispensable for mitogenic signaling, suggesting that the primary role of the alpha chains is to confer high affinity binding (Anderson-1995). Furthermore, the IL15RA and IL2RA (GEM:10p1/IL2RA) genes have a similar intron-exon organization and are closely linked in genome." |
|
REL |
See GEM:02q13/IL1A. |
|
REF |
CLO,SEQ,STR,LOC "Anderson DM &: JBC, 270, 29862-29869, 1995 CLO,SEQ,STR "Giri JG &: EMBO J, 14, 3654-3663, 1995 |
|
KEY |
imm, recp, mem |
|
CLA |
coding, basic |
|
LOC |
10 p15-14 |
|
MIM |
MIM: 601070 |
