Gene: [10p1/IL2RA] interleukin 2 receptor, alpha (high affinity; Tac antigen); antigen Tac (antigen CD25; p55; interleukin 2 receptor alpha); [TCGFR TAC ]

FUN

In IL2-receptor complex, alpha subunit which is responsible for high affinity IL2 binding. On the function of IL2 see in GEM:04q2/IL2."

FAG

Genes for other subunits of IL2 receptor are mapped: GEM:22q13/IL2RB; GEM:0Xq131/IL2RG."

GEN

The gene length is 25 kb or more (Leonard-1985). Exons: 8.

MOP

[1] Interleukin 2 receptor (R-IL2) consists of alpha, beta and gamma subunits encoded by different genes. A heterodimer composed of alpha and beta subunits represents the high-affinity R-IL2 form (Tsudo-1986).
[2] In contrast to R-IL2 alpha subunit, the beta subunit (protein p75) seems to be able to bind fibronectin independently and to exhibit the properties of the low-affinity receptor, which is found on the membrane of T lymphocytes much more frequently than the high-affinity one is."

REL

See GEM:02q13/IL1A.

REF

POL,MOL "Ardlinger, Murray: NAR, 16, 8201, 1988
CLO,SEQ,EXP "Cosman O &: Nature, 312, (20/27 Dec), 768-771, 1984
FUN,GEN,EXP "Depper &: PNAS, 82, N12, 4230-4234, 1985
LOC,MOL "Ferrari S &: AJHG, 41, 616-626, 1987
REV,FUN,GEN,PAT "Greene WC &: Cancer Invest, 5, N4, 369-376, 1987a
REV,FUN,GEN,PAT "Greene WC: Clin Res, 35, N5, 439-450, 1987b
FUN,GEN,EXP "Hatakeyama M &: PNAS, 83, N24, 9650-9654, 1986
FUN,GEN,EXP "Hatakeyama M &: Nature, 318, 467-470, 1985
GEN,CLO,SEQ "Ishida N &: NAR, 13, N21, 7579-7589, 1985
REV,FUN,GEN,PAT "Kanamori H &: Cold Spring Harbor Symp, 51, (Part 2), 739-749, 1986
FUN,GEN,EXP "Kondo &: Nature, 320, 75-77, 1986
FUN,GEN,EXP "Leonard WJ &: PNAS, 82, N18, 6281-6285, 1985a
LOC,MOL "Leonard WJ &: Science, 228, (28 Jun), 1547-1549, 1985b
GEN,CLO,SEQ "Leonard WJ &: Science, 230, (8 Nov), 633-639, 1985c
CLO,SEQ,EXP "Leonard WJ &: Nature, 311, (18 Oct), 626-631, 1984
FUN,GEN,EXP "Leonard WJ &: PNAS, 80, 6957-6961, 1983
CLO,SEQ,EXP "Nikaido T &: Nature, 311, (18 Oct), 631-635, 1984
MUT,ENG,FUN,EXP "Robb RJ &: PNAS, 85, N15, 5654-5658, 1988
FUN,GEN,EXP "Tsudo &: PNAS, 83, N24, 9694-9698, 1986
FUN,GEN,EXP "Urdal &: PNAS, 81, 6481-6485, 1984

SWI

 SWISSPROT: P01589

KEY

imm, recp, mem

CLA

coding, basic

LOC

10 p15-14

MIM

 MIM: 147730

SYN

TCGFR TAC

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