Gene: [17p131/POLR2A] RNA polymerase II (DNA directed) polypeptide A (220kD); nucleotidyltransferase II, RNA-, heavy subunit A;
FAG | RNA polymerase II consists of 12 different subunits: GEM:17p131/POLR2A; GEM:04q12/POLR2B; GEM:16q/POLR2C; GEM:02q21/POLR2D; GEM:19p133/POLR2E; GEM:00.0/POLR2F; GEM:11q131/POLR2G; GEM:00.0/POLR2H; GEM:19q131/POLR2I; GEM:00.0/POLR2J; GEM:00.0/POLR2K; GEM:11p15/POLR2L." |
MUT | Strains of cultured human diploid fibroblasts with supposed structural mutations of polymerase II heavy subunit were revealed. They are identified in the test for alpha-amanitin resistance." |
FUN | The reaction catalyzed: N nucleoside triphosphate = N pyrophosphate + RNA(N)." |
REF | MUT "Buchwald, Ingles: Somat Cell Genet, 2, 225-233, 1976 LOC,PRO "Cannizzaro &: AJHG, 38, 812-818, 1986 GEN,PRO,FAG "Cho KW &: JBC, 260, N28, 15204-15210, 1985 SEQ,EXP,MOP "Pati UK, Weissman: JBC, 264, N22, 13114-13121, 1989 MOU,LOC "Pravtcheva D &: Somat Cell Mol Genet, 12, 523-528, 1986 PEP,EVO "Sweetser &: PNAS, 84, N5, 1192-1196, 1987 LOC,LIN "van Tuinen &: AJHG, 43, 587-596, 1988 |
SWI | SWISSPROT: P24928 |
KEY | nucm, trc |
CLA | coding, basic |
LOC | 17 p13.1 |
MIM | MIM: 180660 |
EZN | ENZYME: 2.7.7.6 |
