Gene: [17q112/RARA] retinoic acid receptor, alpha; acute promyelocytic leukemia breakpoint cluster region; [RAR APL ]

COM

Analyzing the RARA gene in the t(15;17)(q22;q11.2-q12) translocation associated with acute promyelocytic leukemia (APL), De The-1990 identified a new gene on chromosome 15 which is involved with the RARA gene in the formation of a fusion product (GEM:15q22/PML)."

FAG

Genes for retinoic acid receptor beta and gamma peptides are identified (GEM:03p24/RARB; GEM:12q13/RARG)."

MAP

See FAM:SCYA/00.0.

REF

LOC,MOL,POL "Arveiler &: NAR, 16, 6252, 1988
LOC,PAT,MOL,EXP "Borrow J &: Science, 249, 1577-1580, 1990
LOC,FUN,FAG "Brand N &: Nature, 332, 850-853, 1988
EXP,ABR "De The H &: Cell, 66, 675-684, 1991
IDN,LOC,PAT,EXP,ABR "De The H &: Nature, 347, 558-561, 1990
LOC,FAG,EAG,HUM,MOU "Mattei MG &: Genomics, 10, N4, 1061-1069, 1991
LOC "Mattei MG &: Hum Genet, 80, 186-188, 1988
LOC,MAG "Naruse K &: Genomics, 34, 236-240, 1996
PRO,SEQ "Petkovich M &: Nature, 330, 444-450, 1987
FUN,PEP "Robertson M: Nature, 330, 420-421, 1987

SWI

 SWISSPROT: P10276

KEY

hem, onc, vit, recp

CLA

coding, basic

LOC

17 q11.2

MIM

 MIM: 180240

SYN

RAR APL

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