Gene: [19p133/ELA2] elastase 2 (neutrophil?);

COM

The gene NE (GEM:11q14/ELA3) is expressed predominantly in bone marrow promyelocytes; the macrophage phagolysosomes are only a secondary depot. Therefore its conventional denotation NE (Neutrophil Elastase) is not quite correct. The MIM Catalogue describes it as medullasin."

FAG

[1] There are at least three different enzymes that are called 'elastase'. The isoform 1 (GEM:12p1/ELA1), which is synthesized by pancreatic acinar cells, is a serine protease hidrolysing many proteins, including elastin (an unsoluble connective tissue protein, see GEM:07q1123/ELN).
[2] ELA2 gene is cloned as a part of cDNA and mapped to Chr 19."

REF

CLO,SEQ,EXP "Fletcher TS &: Biochemistry, 26, 7256-7261, 1987
CLO,COD,EXP "Kawashima I &: DNA, 6, 163-172, 1987

KEY

pep, exce

CLA

coding, basic

LOC

19 p13.3

MIM

MIM: 130130

EZN

ENZYME: 3.4.21.37