Gene: [11q14/ELA3] elastase 3, neutrophil (medullasin, bone marrow serine protease);
|
COM |
NE is mentioned under MIM:130120 in description of ELA1. |
|
TIS |
ELA3 is expressed primarily in promyelocytes of bone marrow, while the macrophage phagolysosomes serve only for secondary storage. Therefore the conventional name neutrophil elastase (NE) is not quite correct." |
|
FUN |
Elastase 3 is a metalloproteinase; its activity is not suppressed by alpha-1 protease inhibitor (see antitrypsin, GEM:14q321/PI1), in contrast to the elastase 1 activity." |
|
FAG |
There are at least three different enzymes named 'elastase', and much controversion exists in literature on this item. Elastase 1 (GEM:12p1/ELA1) is a serine protease synthesized by the pancreatic acinar cells. It hydrolyses many proteins, including elastin (an unsoluble connective tissue protein, GEM:07q1123/ELN). Gene ELA2 was identified (cDNA cloned and the amino acid sequence of the protein determined) and mapped to chr 19 (GEM:19p133/ELA2)." |
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REF |
CLO,SEQ,COD,EXP "Aoki Y, Hase T: BBRC, 178, 501-506, 1991 IDN,MEB,FUN "Aoki Y: JBC, 283, 2026-2032, 1978 CLO,SEQ,GEN,PEP,EXP "Nakamura H &: NAR, 15, 9601-9602, 1987 CLO,SEQ,COD,EXP "Okano K &: BBRC, 167, 1326-1332, 1990 CLO,SEQ,COD,EXP "Okano K &: J Biochem, 102, 13-16, 1987 FUN,PEP,SEQ,EVO "Sinha S &: PNAS, 84, N8, 2228-2232, 1987 GEN,SEQ,MOP,LOC "Takahashi H &: JBC, 263, N29, 14739-14747, 1988 |
|
KEY |
pulm, pep |
|
CLA |
coding, basic |
|
LOC |
11 q14 |
|
MIM |
MIM: 130130 |
|
EZN |
ENZYME: 3.4.21.37 |
