Gene: [19q134/TNNT1] troponin T1, skeletal, slow; [TNT ]

FUN

Troponin T (tropomyosin-binding) is a constituent protein of the troponin complex located on the thin filament of striated (skeletal and cardiac) muscle and provided a calcium-sensitive switch for striated muscle contraction (see details in FAM:TNN/00.0)."

FAG

The contraction of skeletal muscles is regulated by the Ca-dependent protein complex containing tropomyosin dimers (on tropomyosin genes see in: GEM:15q221/TPM1) and 2-3 troponin peptides (on troponin genes see in: FAM:TNN/00.0; on troponin T genes see in: FAM:TNN/00.0)."

REF

EXP,SEQ,MEB,FUN "Gahlmann R &: JBC, 262, 16122-16126, 1987
FUN,MEB "Nadal-Ginard, Mahdavi: J Clin Invest, 84, 1693-1700, 1989
CLO,COD,SEQ,LOC,ASS,EXP "Samson F &: J Neurosci Res, 27, 441-451, 1990

KEY

myo

CLA

coding, basic

LOC

19 q13.4

MIM

MIM: 191041

SYN

TNT

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