Gene: [HOXB/17q2] homeo box region B, gene cluster on chr 17q2; (HOXB1 HOXB2 HOXB3 HOXB4 HOXB5 HOXB6 HOXB7 HOXB8 HOXB9 HOXB13)

SUM

 [1] Precise number of all human homeosis genes is unknown. Four HOX gene clusters have been currently mapped: HOXD (chr 2q31), HOXA (chr 7p1), HOXC (chr 12q1), HOXB (chr 17q2). MSX1 gene has also been mapped (GEM:04p161/MSX1).
[2] Data on fine physical mapping of this region of chr 17q have been obtained (Bentley-1989). Thus, it was shown that, within HOXB cluster, B5 and B6 genes were located no more than 5 kb apart, and B7 gene was located 50 kb from gene B5. In addition, this cluster was demonstrated to be physically linked to the nerve growth factor receptor gene (GEM:17q2/NGFR) and to be located about 600 kb from it, since the gene-specific DNA probes for these genes recognized a common 590-kb MluI fragment in DNA endohydrolyzate of chr 17. On the close physical linkage of the genes for nerve growth factor receptor and collagen alpha-1(I), see GEM:17q2/COL1A1."

MAP

 Loci: GEM:17q112/NF1; GEM:17q1/EGFR2; GEM:17q1/THRA; GEM:17q2/NGFR.
[1] See GEM:17q112/NF1."

REF

 LIN,MOL,MAF "Bentley &: CCG, 51, (HGM10), 961, 1989
PRO,SEQ,EVO "Boncinelli &: Cold Spring Harbor Symp, 50, 301-306, 1985
LOC,MOL,REV "Cannizzaro LA &: AJHG, 41, 1-15, 1987
LOC,EAG "Joyner AL &: Nature, 314, (14 Mar), 173-175, 1985
PRO,SEQ,EVO "Levine M &: Cell, 38, N3, 667-673, 1984
NOM "McAlpine PJ, Shows: Genomics, 7, N3, 460, 1990
POL,MOL "Murphy PD &: NAR, 15, N15, 6311, 1987
LOC,EAG "Rabin M &: Nature, 314, (14 Mar), 175-178, 1985
PRO,SEQ,EVO "Simeone A &: PNAS, 84, N14, 4914-4918, 1987
LIN,MOL,MAP "Xu WM &: PNAS, 85, N22, 8563-8567, 1988